Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	2	309	6p21.2	KCNK16	potassium two pore domain channel subfamily K member 16	1
Mouse	4	2	292	14 B	Kcnk16	potassium channel, subfamily K, member 16
Rat	-	2	-	15p16	Kcnk16	potassium two pore domain channel subfamily K member 16

Previous and Unofficial Names

TALK1 | potassium channel, two pore domain subfamily K, member 16 | potassium channel

Database Links
Alphafold	Q96T55 (Hs)
Ensembl Gene	ENSG00000095981 (Hs), ENSMUSG00000023387 (Mm), ENSRNOG00000006422 (Rn)
Entrez Gene	83795 (Hs), 74571 (Mm), 688996 (Rn)
Human Protein Atlas	ENSG00000095981 (Hs)
KEGG Gene	hsa:83795 (Hs), mmu:74571 (Mm), rno:688996 (Rn)
OMIM	607369 (Hs)
Pharos	Q96T55 (Hs)
RefSeq Nucleotide	NM_032115 (Hs), NM_029006 (Mm), NM_001109520 (Rn)
RefSeq Protein	NP_115491 (Hs), NP_083282 (Mm), NP_001102990 (Rn)
UniProtKB	Q96T55 (Hs)
Wikipedia	KCNK16 (Hs)

Functional Characteristics
Background current

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference isoflurane Hs - - - 7x10-4 - 9x10-4 - 1 ⤷ Conc range: 7x10-4 - 9x10-4 M [1] NO Hs - - - - - 1 ⤷ [1]

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference Ba2+ Hs - - - 1x10-3 - 1 ⤷ Conc range: 1x10-3 M [1] chloroform Hs - - - 7x10-4 - 8x10-4 - 1 ⤷ Conc range: 7x10-4 - 8x10-4 M [1] quinidine Hs - - - 1x10-4 - 1 ⤷ Conc range: 1x10-4 M [1]

Tissue Distribution
Placenta. Species:  Human Technique:  Northern Blot, cDNA cloning References:  1-2

Biologically Significant Variant Comments

Alternatively spliced products have been reported but their pharmacological and physiological significance has not been ascertained.

General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. The open probability of both K2P16 and 17 increases with external pH. At present it is unclear if this represents proton block at physiological levels or activation of the channel by supra-physiological alkaline pHo. There are four splice variants of K2P16, two of which are functional [2].