Contents:
Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 4 | 2 | 430 | 2p16.3 | KCNK12 | potassium two pore domain channel subfamily K member 12 | 5 |
| Mouse | 4 | 2 | 430 | 17 E4 | Kcnk12 | potassium channel, subfamily K, member 12 | |
| Rat | 4 | 2 | 430 | 6q12 | Kcnk12 | potassium two pore domain channel subfamily K member 12 | |
| Previous and Unofficial Names |
| THIK-2 | tandem pore domain halothane-inhibited potassium channel 2 | tandem pore domain potassium channel THIK-2 | mntk1 | potassium channel, two pore domain subfamily K, member 12 | potassium channel |
| Database Links |
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| Alphafold | Q9HB15 (Hs), Q9ERS1 (Rn) |
| Ensembl Gene | ENSG00000184261 (Hs), ENSMUSG00000050138 (Mm), ENSRNOG00000016110 (Rn) |
| Entrez Gene | 56660 (Hs), 210741 (Mm), 64119 (Rn) |
| Human Protein Atlas | ENSG00000184261 (Hs) |
| KEGG Gene | hsa:56660 (Hs), mmu:210741 (Mm), rno:64119 (Rn) |
| OMIM | 607366 (Hs) |
| Pharos | Q9HB15 (Hs) |
| RefSeq Nucleotide | NM_022055 (Hs), NM_199251 (Mm), NM_022292 (Rn) |
| RefSeq Protein | NP_071338 (Hs), NP_954859 (Mm), NP_071628 (Rn) |
| UniProtKB | Q9HB15 (Hs), Q9ERS1 (Rn) |
| Wikipedia | KCNK12 (Hs) |
| Associated Proteins |
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| Associated Protein Comments | ||||||||||||||||||||
| Heteromultimers shown to form in vivo: Heterodimerization of K2P12 and K2P13 was recently reported in a heterologous expression system [1]. Protein-protein interactions: An N-terminal endoplasmic retention signal has been reported [2,6] but no protein partners have been identified. |
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| Functional Characteristics |
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| Does not function as a homodimer [5] but can form a functional heterodimer with K2P13 [1]. | |
Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Tissue Distribution
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| Tissue Distribution Comments | ||||||||||
| Expression has also been reported in brain, heart, lung, kidney, liver, small intestine, colon, pancreas, prostate, placenta, spleen, thymus, and ovary. | ||||||||||
| Gene Expression and Pathophysiology Comments | |
| High expression K2P12 is associated with resistance of lymphomas/leukemias to antitumor γδ T-cell cytotoxicity [3]. Elevated expression of K2P12 was found to be associated with poor ‘progression-free survival’ in B-cell lymphoma [4]. |
References
1. Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D. (2014) Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. J Biol Chem, 289 (41): 28202-12. [PMID:25148687]
2. Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F. (2013) Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. J Biol Chem, 288 (49): 35081-92. [PMID:24163367]
3. Gomes AQ, Correia DV, Grosso AR, Lança T, Ferreira C, Lacerda JF, Barata JT, Silva MG, Silva-Santos B. (2010) Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells. Haematologica, 95 (8): 1397-404. [PMID:20220060]
4. Kim SJ, Sohn I, Do IG, Jung SH, Ko YH, Yoo HY, Paik S, Kim WS. (2014) Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay. Ann Hematol, 93 (3): 437-47. [PMID:23975159]
5. Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C. (2001) THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J Biol Chem, 276 (10): 7302-11. [PMID:11060316]
6. Renigunta V, Zou X, Kling S, Schlichthörl G, Daut J. (2014) Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Pflugers Arch, 466 (9): 1735-45. [PMID:24297522]
7. Theilig F, Goranova I, Hirsch JR, Wieske M, Unsal S, Bachmann S, Veh RW, Derst C. (2008) Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. Cell Physiol Biochem, 21 (1-3): 63-74. [PMID:18209473]
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