Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	12	0	816	12q24.13	TPCN1	two pore segment channel 1
Mouse	12	0	817	5 F	Tpcn1	two pore channel 1
Rat	12	0	817	12q16	Tpcn1	two pore segment channel 1

Previous and Unofficial Names

two pore calcium channel protein 1 | two pore channel 1 | voltage-gated Ca channel

Database Links
Alphafold	Q9ULQ1 (Hs), Q9EQJ0 (Mm), Q9WTN5 (Rn)
Ensembl Gene	ENSG00000186815 (Hs), ENSMUSG00000032741 (Mm), ENSRNOG00000059344 (Rn)
Entrez Gene	53373 (Hs), 252972 (Mm), 246215 (Rn)
Human Protein Atlas	ENSG00000186815 (Hs)
KEGG Gene	hsa:53373 (Hs), mmu:252972 (Mm), rno:246215 (Rn)
OMIM	609666 (Hs)
Pharos	Q9ULQ1 (Hs)
RefSeq Nucleotide	NM_017901 (Hs), NM_145853 (Mm), NM_139332 (Rn)
RefSeq Protein	NP_060371 (Hs), NP_665852 (Mm), NP_647548 (Rn)
UniProtKB	Q9ULQ1 (Hs), Q9EQJ0 (Mm), Q9WTN5 (Rn)
Wikipedia	TPCN1 (Hs)

Functional Characteristics
Organelle voltage-gated Na+-selective channel (Na+>>K+>>Ca2+); Required for the generation of action potential-like long depolarization in lysosomes. Voltage-dependence of activation is sensitive to luminal pH (determined from lysosomal recordings). ψ1/2 @ pH4.6 = +91 mV; ψ1/2 @ pH6.5 = +2.6 mV. Maximum activity requires PI(3,5)P2 and reduced [ATP], or depletion of extracellular amino acids.

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference phosphatidyl (3,5) inositol bisphosphate Hs Activation 6.5 pEC50 - - 1 ⤷ pEC50 6.5 (EC50 3x10-7 M) [1]

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference verapamil Hs Inhibition 4.6 pIC50 - - 1 ⤷ pIC50 4.6 (IC50 2.3x10-5 M) [1] Cd2+ Hs Inhibition 3.7 pIC50 - - 1 ⤷ pIC50 3.7 (IC50 1.8x10-4 M) [1]

Immuno Process Associations

Immuno Process:  Antigen presentation GO Annotations:  Associated to 1 GO processes GO:0075509 endocytosis involved in viral entry into host cell IMP

Immuno Process:  Barrier integrity GO Annotations:  Associated to 1 GO processes GO:0075509 endocytosis involved in viral entry into host cell IMP