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Plasmodium falciparum adenylyl cyclase beta

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Target id: 3197

Nomenclature: Plasmodium falciparum adenylyl cyclase beta

Abbreviated Name: PfACbeta

Family: Cyclic nucleotide turnover/signalling (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 2279 ACbeta adenylyl cyclase beta
Previous and Unofficial Names Click here for help
MAL8P1.150 | ACβ | adenylyl cyclase-β
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
KH7 Small molecule or natural product Guide to Malaria Pharmacology Ligand Pf Inhibition 5.3 pIC50 2
pIC50 5.3 (IC50 5x10-6 M) [2]
Malaria Pharmacology Comments
The enzyme adenylyl cyclase (AC) converts ATP to cyclic AMP and pyrophosphate, with the P. falciparum genome encoding two ACs, PfACalpha and PfACbeta (described here).
PfACbeta has been shown to have an important role during the asexual blood stage of the Plasmodium lifecycle and to be selectively targeted by small molecule inhibitors [2]. It is a target "under consideration" in the Malaria Drug Accelerator (MalDA) portfolio [1].

References

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1. Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK et al.. (2021) Prioritization of Molecular Targets for Antimalarial Drug Discovery. ACS Infect Dis, 7 (10): 2764-2776. [PMID:34523908]

2. Salazar E, Bank EM, Ramsey N, Hess KC, Deitsch KW, Levin LR, Buck J. (2012) Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. PLoS One, 7 (6): e39769. [PMID:22761895]

How to cite this page

Cyclic nucleotide turnover/signalling (Plasmodium spp.): Plasmodium falciparum adenylyl cyclase beta. Last modified on 13/12/2021. Accessed on 17/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3197.