Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	2279		ACbeta	adenylyl cyclase beta

Previous and Unofficial Names

ACbeta | Pf3D7_08_v3:180,040..188,229(+) | MAL8P1.150 | ACβ | adenylyl cyclase-β

Database Links
Alphafold	C0H4R1 (Pf3D7)
PlasmoDB	PF3D7_0802600 (Pf3D7)
UniProtKB	C0H4R1 (Pf3D7)

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Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference KH7 Pf Plasmodium falciparum P. falciparum (Pf) is one of five protozoan parasite species of the genus Plasmodium that cause malaria in humans. Pf is responsible for the majority of malaria related deaths and is the most prevalent species in sub-Saharan Africa. ✖ Inhibition 5.3 pIC50 2 ⤷ pIC50 5.3 (IC50 5x10-6 M) [2]

Malaria Pharmacology Comments

The enzyme adenylyl cyclase (AC) converts ATP to cyclic AMP and pyrophosphate, with the P. falciparum genome encoding two ACs, PfACalpha and PfACbeta (described here). PfACbeta has been shown to have an important role during the asexual blood stage of the Plasmodium lifecycle and to be selectively targeted by small molecule inhibitors [2]. It is a target "under consideration" in the Malaria Drug Accelerator (MalDA) portfolio [1].