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FKBP prolyl isomerase 8

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Target id: 3177

Nomenclature: FKBP prolyl isomerase 8

Abbreviated Name: FKBP38

Family: Peptidyl-prolyl cis/trans isomerases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 413 19p13.11 FKBP8 FKBP prolyl isomerase 8
Mouse - 403 Ch 8, 34.15 cM, cytoband C1 Fkbp8 FK506 binding protein 8
Rat - 403 16p14 Fkbp8 FKBP prolyl isomerase 8
Previous and Unofficial Names Click here for help
K506 binding protein 8 | FKBP38 | FKBPr38 | K506-binding protein 8 (38kD)
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GPI-1046 Small molecule or natural product Ligand has a PDB structure Hs - 7.3 pKi 1
pKi 7.3 (Ki 4.8x10-8 M) [1]
DM-CHX Small molecule or natural product Hs - 7.1 pKi 1
pKi 7.1 (Ki 8.5x10-8 M) [1]


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1. Edlich F, Weiwad M, Wildemann D, Jarczowski F, Kilka S, Moutty MC, Jahreis G, Lücke C, Schmidt W, Striggow F et al.. (2006) The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. J Biol Chem, 281 (21): 14961-70. [PMID:16547004]


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