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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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More detailed introduction
Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [17], and family members have been targetted for immunosuppressant effects.
FKBP12 (FKBP prolyl isomerase 1A)
C
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FKBP38 (FKBP prolyl isomerase 8)
C
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FKBP51 (FKBP prolyl isomerase 5)
C
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FKBP52 (FKBP prolyl isomerase 4)
C
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FKBP prolyl isomerase like
C
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peptidylprolyl cis/trans isomerase, NIMA-interacting 1
C
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Cyclophilin A (peptidylprolyl isomerase A)
C
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Cyclophilin D (peptidylprolyl isomerase D)
C
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Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.