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Plasmodium falciparum acetyl-CoA synthetase

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Target id: 3174

Nomenclature: Plasmodium falciparum acetyl-CoA synthetase

Abbreviated Name: PfACS

Family: Other antimalarial targets

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 997 ACS acetyl-CoA synthetase, putative
Previous and Unofficial Names Click here for help
ACS | acetyl-CoA synthetase, putative
Database Links Click here for help
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
MMV689258 Small molecule or natural product Pf - - 8.3 pIC50 1
pIC50 8.3 (IC50 5x10-9 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)


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1. Schalkwijk J, Allman EL, Jansen PAM, de Vries LE, Verhoef JMJ, Jackowski S, Botman PNM, Beuckens-Schortinghuis CA, Koolen KMJ, Bolscher JM et al.. (2019) Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum. Sci Transl Med, 11 (510). [PMID:31534021]

How to cite this page

Other antimalarial targets: Plasmodium falciparum acetyl-CoA synthetase. Last modified on 17/03/2021. Accessed on 18/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY,