Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	559		aTrpRS	tryptophan--tRNA ligase
Gene and Protein Information Comments
The Plasmodium genome encodes two forms of tryptophanyl-tRNA synthetase, one found in the cytoplasm (PfcWRS, encoded by PF3D7_1336900) and one in the apicoplast (PfaWRS, described here).

Previous and Unofficial Names

Pf3D7_12_v3:2,105,871..2,108,564(-) | PfaTrpRS | TrpRSapi | PFL2485c | Plasmodium falciparum tryptophan--tRNA ligase

Database Links
Alphafold	A0A144A140 (Pf3D7)
PlasmoDB	PF3D7_1251700 (Pf3D7)
UniProtKB	A0A144A140 (Pf3D7)

Whole Organism Assay Data Linked to This Target
Key to terms and symbols		Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference indolmycin Pf3D7 Plasmodium falciparum 3D7 P. falciparum strain 3D7 (Pf3D7) was derived from isolate NF54 by limiting dilution. The complete genome of Pf3D7 has been sequenced (GenBank: LN999946.1). Pf3D7 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is sensitive to a panel of antimalarial compounds including chloroquine and pyrimethamine. ✖ - - 5.8 pIC50 1 ⤷ pIC50 5.8 (IC50 1.7x10-6 M) SYBR Green susceptibility assay determined 96 hrs after drug treatment [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)