Plasmodium falciparum cyclin-dependent-like kinase CLK3 | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum cyclin-dependent-like kinase CLK3

Target id: 3105

Nomenclature: Plasmodium falciparum cyclin-dependent-like kinase CLK3

Abbreviated Name: PfCLK3

Family: Antimalarial targets

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 699 CLK3 cyclin-dependent-like kinase CLK3
Database Links
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
TCMDC-135051 PfDd2 - - 6.9 pEC50 1
pEC50 6.9 (EC50 1.13x10-7 M) [1]
TCMDC-135051 Pf3D7 - - 6.5 pEC50 1
pEC50 6.5 (EC50 3.2x10-7 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
TCMDC-135051 Pb - - 6.4 pEC50 1
pEC50 6.4 (EC50 4x10-7 M) [1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Malaria Pharmacology Comments
P. falciparum cyclin-dependent-like kinase CLK3 (PfCLK3) has been validated as an antimalarial target acting at multiple parasite life stages [1]. PfCLK3 is one of four members of the cyclin-dependent like protein kinase family (PfCLK1-4) with a key role in pre-RNA splicing and processing.

References

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1. Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y et al.. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science, 365 (6456). [PMID:31467193]

How to cite this page

Antimalarial targets: Plasmodium falciparum cyclin-dependent-like kinase CLK3. Last modified on 24/09/2020. Accessed on 26/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3105.