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Plasmodium falciparum cyclin-dependent-like kinase CLK3

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Target id: 3105

Nomenclature: Plasmodium falciparum cyclin-dependent-like kinase CLK3

Abbreviated Name: PfCLK3

Family: Kinases (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 699 CLK3 cyclin-dependent-like kinase CLK3
Previous and Unofficial Names Click here for help
PF11_0156
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
TCMDC-135051 Small molecule or natural product Guide to Malaria Pharmacology Ligand PfDd2 - - 6.9 pEC50 1
pEC50 6.9 (EC50 1.13x10-7 M) [1]
TCMDC-135051 Small molecule or natural product Guide to Malaria Pharmacology Ligand Pf3D7 - - 6.5 pEC50 1
pEC50 6.5 (EC50 3.2x10-7 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
TCMDC-135051 Small molecule or natural product Guide to Malaria Pharmacology Ligand Pb - - 6.4 pEC50 1
pEC50 6.4 (EC50 4x10-7 M) [1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Malaria Pharmacology Comments
P. falciparum cyclin-dependent-like kinase CLK3 (PfCLK3) has been validated as an antimalarial target acting at multiple parasite life stages [1]. PfCLK3 is one of four members of the cyclin-dependent like protein kinase family (PfCLK1-4) with a key role in pre-RNA splicing and processing.

References

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1. Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y et al.. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science, 365 (6456). [PMID:31467193]

How to cite this page

Kinases (Plasmodium spp.): Plasmodium falciparum cyclin-dependent-like kinase CLK3. Last modified on 11/10/2021. Accessed on 21/01/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3105.