Plasmodium falciparum type II NADH:ubiquinone oxidoreductase | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum type II NADH:ubiquinone oxidoreductase

Target id: 3090

Nomenclature: Plasmodium falciparum type II NADH:ubiquinone oxidoreductase

Abbreviated Name: PfNDH2

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 533 NDH2 type II NADH:ubiquinone oxidoreductase
Database Links
PlasmoDB
UniProtKB
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  The structure of malaria PfNDH2
PDB Id:  5JWA
Resolution:  2.162Å
Species:  Plasmodium falciparum 3D7
References:  3
Malaria Pharmacology Comments
Type II NADH:ubiquinone oxidoreductase (NDH2) is an enzyme in the mitochondrial electron transport chain that is not present in mammals but is found in many species including those of the malaria parasite. It has been considered to be a promising antimalarial drug target for a number of years, but a recent study questions this with the demonstration that PfNDH2 is not essential in the asexual blood stages of P. falciparum development [2]. In the P. berghei mouse model, NDH2 has been shown to be essential for sporogony inside the mosquito vector and may be required for malaria transmission [1].

References

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1. Boysen KE, Matuschewski K. (2011) Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase. J. Biol. Chem., 286 (37): 32661-71. [PMID:21771793]

2. Ke H, Ganesan SM, Dass S, Morrisey JM, Pou S, Nilsen A, Riscoe MK, Mather MW, Vaidya AB. (2019) Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages. PLoS ONE, 14 (4): e0214023. [PMID:30964863]

3. Yang Y, Yu Y, Li X, Li J, Wu Y, Yu J, Ge J, Huang Z, Jiang L, Rao Y et al.. (2017) Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria. J. Med. Chem., 60 (5): 1994-2005. [PMID:28195463]

How to cite this page

Antimalarial targets: Plasmodium falciparum type II NADH:ubiquinone oxidoreductase. Last modified on 08/07/2019. Accessed on 19/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3090.