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Target id: 3083
Nomenclature: S100 calcium binding protein A11
Systematic Nomenclature: S100A11
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 105 | 1q21.3 | S100A11 | S100 calcium binding protein A11 | |
Mouse | - | 98 | 3 F2.1 | S100a11 | S100 calcium binding protein A11 | |
Rat | - | 98 | 2q34 | S100a11 | S100 calcium binding protein A11 |
Previous and Unofficial Names | |
calgizzarin [9] | MLN70 | S100-A11 |
Database Links | |
Alphafold | P31949 (Hs), P50543 (Mm), Q6B345 (Rn) |
Ensembl Gene | ENSG00000163191 (Hs), ENSMUSG00000027907 (Mm), ENSRNOG00000010105 (Rn) |
Entrez Gene | 6282 (Hs), 20195 (Mm), 445415 (Rn) |
Human Protein Atlas | ENSG00000163191 (Hs) |
KEGG Gene | hsa:6282 (Hs), mmu:20195 (Mm), rno:445415 (Rn) |
OMIM | 603114 (Hs) |
Pharos | P31949 (Hs) |
RefSeq Nucleotide | NM_005620 (Hs), NM_016740 (Mm), NM_001004095 (Rn) |
RefSeq Protein | NP_005611 (Hs), NP_058020 (Mm), NP_001004095 (Rn) |
UniProtKB | P31949 (Hs), P50543 (Mm), Q6B345 (Rn) |
Wikipedia | S100A11 (Hs) |
Immunopharmacology Comments |
S100A11 is a pro-inflammatory calcium-binding protein. Elevated S100A11 has been reported as a marker of disease activity and extramuscular manifestations in inflammatory myopathies [1], and as a diagnostic marker that can distinguish systemic lupus erythematosus patients from healthy controls [4,11]. |
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General Comments |
S100A11 is expressed in a variety of human tissues including skin, placenta, lung, PBMCs, kidney and heart, but it is not expressed in the brain [6]. Expression is elevated in some cancers [8,10], and in chronic inflammatory diseases [2,4]. The protein localises in the nucleus, cytoplasm and cell periphery [3,5,7]. S100A11 contains 2 EF-hand Ca2+-binding motifs. |
1. Andrés Cerezo L, Hulejová H, Šumová B, Kropáčková T, Kryštůfková O, Klein M, Mann HF, Zámečník J, Pecha O, Pavelka K et al.. (2019) Pro-inflammatory S100A11 is elevated in inflammatory myopathies and reflects disease activity and extramuscular manifestations in myositis. Cytokine, 116: 13-20. [PMID:30684913]
2. Andrés Cerezo L, Šumová B, Prajzlerová K, Veigl D, Damgaard D, Nielsen CH, Pavelka K, Vencovský J, Šenolt L. (2017) Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis. Arthritis Res Ther, 19 (1): 79. [PMID:28446208]
3. Broome AM, Eckert RL. (2004) Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. J Invest Dermatol, 122 (1): 29-38. [PMID:14962086]
4. Cerezo LA, Šumová B, Hulejová H, Štorkánová H, Szczuková L, Tomčík M, Bečvář R, Pavelka K, Vencovský J, Závada J et al.. (2019) S100A11 (calgizzarin) is released by circulating mononuclear cells and its elevated plasma levels distinguish systemic lupus erythematosus patients from healthy individuals. Clin Exp Rheumatol, 37 (2): 338-339. [PMID:30719969]
5. Cross SS, Hamdy FC, Deloulme JC, Rehman I. (2005) Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers. Histopathology, 46 (3): 256-69. [PMID:15720411]
6. Sakaguchi M, Miyazaki M, Takaishi M, Sakaguchi Y, Makino E, Kataoka N, Yamada H, Namba M, Huh NH. (2003) S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes. J Cell Biol, 163 (4): 825-35. [PMID:14623863]
7. Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, Yamada H, Huh NH. (2008) S100A11, an dual mediator for growth regulation of human keratinocytes. Mol Biol Cell, 19 (1): 78-85. [PMID:17978094]
8. Tanaka M, Adzuma K, Iwami M, Yoshimoto K, Monden Y, Itakura M. (1995) Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. Cancer Lett, 89 (2): 195-200. [PMID:7889529]
9. Todoroki H, Kobayashi R, Watanabe M, Minami H, Hidaka H. (1991) Purification, characterization, and partial sequence analysis of a newly identified EF-hand type 13-kDa Ca(2+)-binding protein from smooth muscle and non-muscle tissues. J Biol Chem, 266 (28): 18668-73. [PMID:1917990]
10. Tomasetto C, Régnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC. (1995) Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. Genomics, 28 (3): 367-76. [PMID:7490069]
11. Šumová B, Cerezo LA, Szczuková L, Nekvindová L, Uher M, Hulejová H, Moravcová R, Grigorian M, Pavelka K, Vencovský J et al.. (2019) Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study. Rheumatol Int, 39 (3): 469-478. [PMID:30392117]
EF-hand domain containing proteins: S100 calcium binding protein A11. Last modified on 01/05/2019. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3083.