Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	205		HDP	heme detoxification protein

Previous and Unofficial Names

Plasmodium falciparum heme ligase

Database Links
ChEMBL Target	CHEMBL4105720 (Pf3D7)
UniProtKB	Q8IL04 (Pf3D7)

Whole Organism Assay Data Linked to This Target
Key to terms and symbols		Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference compound 3a [PMID: 30344903] PfFCR3 Plasmodium falciparum FCR3 P. falciparum strain FCR3 (PfFCR3) was originally isolated from a patient in The Gambia, West Africa in 1976. PfFCR3 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4). Differences in sensitivity of PfFCR3 clones to chloroquine have been reported, with the original isolate that was chloroquine sensitive rapidly acquiring resistance in culture (PMID: 7031656, PMID: 51801). ✖ Parasite growth inhibition assay - - 7.7 pIC50 2 ⤷ pIC50 7.7 (IC50 2x10-8 M) Parasite lactate dehydrogenase (pLDH) assay [2] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont) compound 3a [PMID: 30344903] PfK1 Plasmodium falciparum K1 P. falciparum strain K1 (PfK1) was isolated in Kanchanaburi, Thailand in 1979. PfK1 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is reported to be a multidrug-resistant strain. ✖ Parasite growth inhibition assay - - 7.3 pIC50 2 ⤷ pIC50 7.3 (IC50 4.5x10-8 M) Parasite lactate dehydrogenase (pLDH) assay [2] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

Malaria Pharmacology Comments

Heme Detoxification Protein (HDP) appears to be unique to Plasmodium but is highly conserved across this genus [1].