Plasmodium falciparum heme detoxification protein | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum heme detoxification protein

Target id: 3079

Nomenclature: Plasmodium falciparum heme detoxification protein

Abbreviated Name: PfHDP

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Contents:

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 205 HDP heme detoxification protein
Previous and Unofficial Names
Plasmodium falciparum heme ligase
Database Links
ChEMBL Target CHEMBL4105720 (Pf3D7)
UniProtKB Q8IL04 (Pf3D7)
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
compound 3a [PMID: 30344903] PfFCR3

Plasmodium falciparum FCR3

P. falciparum strain FCR3 (PfFCR3) was originally isolated from a patient in The Gambia, West Africa in 1976.
PfFCR3 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4). Differences in sensitivity of PfFCR3 clones to chloroquine have been reported, with the original isolate that was chloroquine sensitive rapidly acquiring resistance in culture (PMID: 7031656, PMID: 51801).
✖
 Parasite growth inhibition assay - - 7.7 pIC50 2
⤷ pIC50 7.7 (IC50 2x10-8 M) Parasite lactate dehydrogenase (pLDH) assay [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
compound 3a [PMID: 30344903] PfK1

Plasmodium falciparum K1

P. falciparum strain K1 (PfK1) was isolated in Kanchanaburi, Thailand in 1979.
PfK1 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is reported to be a multidrug-resistant strain.
✖
 Parasite growth inhibition assay - - 7.3 pIC50 2
⤷ pIC50 7.3 (IC50 4.5x10-8 M) Parasite lactate dehydrogenase (pLDH) assay [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
Heme Detoxification Protein (HDP) appears to be unique to Plasmodium but is highly conserved across this genus [1].

References

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1. Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D. (2008) HDP-a novel heme detoxification protein from the malaria parasite. PLoS Pathog., 4 (4): e1000053. [PMID:18437218]

2. Sakata Y, Yabunaka K, Kobayashi Y, Omiya H, Umezawa N, Kim HS, Wataya Y, Tomita Y, Hisamatsu Y, Kato N et al.. (2018) Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme. ACS Med Chem Lett, 9 (10): 980-985. [PMID:30344903]

How to cite this page

Antimalarial targets: Plasmodium falciparum heme detoxification protein. Last modified on 26/03/2019. Accessed on 18/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3079.