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Target id: 3079
Nomenclature: Plasmodium falciparum heme detoxification protein
Abbreviated Name: PfHDP
Family: Antimalarial targets
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Plasmodium falciparum 3D7 | - | 205 | HDP | heme detoxification protein |
Previous and Unofficial Names ![]() |
Plasmodium falciparum heme ligase |
Database Links ![]() |
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ChEMBL Target | CHEMBL4105720 (Pf3D7) |
PlasmoDB | PF3D7_1446800 (Pf3D7) |
UniProtKB | Q8IL04 (Pf3D7) |
Whole Organism Assay Data Linked to This Target | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Malaria Pharmacology Comments |
Heme Detoxification Protein (HDP) appears to be unique to Plasmodium but is highly conserved across this genus [1]. |
1. Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D. (2008) HDP-a novel heme detoxification protein from the malaria parasite. PLoS Pathog., 4 (4): e1000053. [PMID:18437218]
2. Sakata Y, Yabunaka K, Kobayashi Y, Omiya H, Umezawa N, Kim HS, Wataya Y, Tomita Y, Hisamatsu Y, Kato N et al.. (2018) Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme. ACS Med Chem Lett, 9 (10): 980-985. [PMID:30344903]
Antimalarial targets: Plasmodium falciparum heme detoxification protein. Last modified on 26/03/2019. Accessed on 19/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3079.