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Plasmodium falciparum heme detoxification protein

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Target id: 3079

Nomenclature: Plasmodium falciparum heme detoxification protein

Abbreviated Name: PfHDP

Family: Haemoglobin degradation pathway enzymes

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 205 HDP heme detoxification protein
Previous and Unofficial Names Click here for help
HDP | heme detoxification protein | Plasmodium falciparum heme ligase
Database Links Click here for help
ChEMBL Target
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
Lys01 Small molecule or natural product PfFCR3 Parasite growth inhibition assay - - 7.7 pIC50 2
pIC50 7.7 (IC50 2x10-8 M) Parasite lactate dehydrogenase (pLDH) assay [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Lys01 Small molecule or natural product PfK1 Parasite growth inhibition assay - - 7.3 pIC50 2
pIC50 7.3 (IC50 4.5x10-8 M) Parasite lactate dehydrogenase (pLDH) assay [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
Heme Detoxification Protein (HDP) appears to be unique to Plasmodium but is highly conserved across this genus [1].

References

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1. Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D. (2008) HDP-a novel heme detoxification protein from the malaria parasite. PLoS Pathog, 4 (4): e1000053. [PMID:18437218]

2. Sakata Y, Yabunaka K, Kobayashi Y, Omiya H, Umezawa N, Kim HS, Wataya Y, Tomita Y, Hisamatsu Y, Kato N et al.. (2018) Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme. ACS Med Chem Lett, 9 (10): 980-985. [PMID:30344903]

How to cite this page

Haemoglobin degradation pathway enzymes: Plasmodium falciparum heme detoxification protein. Last modified on 22/01/2021. Accessed on 29/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3079.