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Y4 receptor

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Target id: 307

Nomenclature: Y4 receptor

Family: Neuropeptide Y receptors

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 375 10q11.22 NPY4R neuropeptide Y receptor Y4 9,20,34
Mouse 7 375 14 20.8 cM Npy4r neuropeptide Y receptor Y4 9,15
Rat 7 375 16p15 Npy4r neuropeptide Y receptor Y4 21,32,34
Previous and Unofficial Names Click here for help
PP1 | neuropeptide Y receptor type 4 | pancreatic polypeptide receptor 1
Database Links Click here for help
Specialist databases
GPCRdb npy4r_human (Hs), npy4r_mouse (Mm), npy4r_rat (Rn)
Other databases
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
neuropeptide Y {Sp: Human, Mouse, Rat}
pancreatic polypeptide {Sp: Human} , pancreatic polypeptide {Sp: Mouse} , pancreatic polypeptide {Sp: Rat}
peptide YY {Sp: Human} , peptide YY {Sp: Mouse, Rat, Pig}
PYY-(3-36) {Sp: Mouse, Rat}
Comments: Peptide YY is the principal endogenous agonist
Potency order of endogenous ligands (Human)
pancreatic polypeptide >> neuropeptide Y = peptide YY

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]PYY (pig) Peptide Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Full agonist 9.8 pKd 20
pKd 9.8 [20]
[125I]GR231118 Peptide Click here for species-specific activity table Ligand is labelled Ligand is radioactive Rn Full agonist 9.6 pKd 10
pKd 9.6 [10]
pancreatic polypeptide {Sp: Human} Peptide Click here for species-specific activity table Rn Full agonist 10.5 – 10.9 pKi 13,32
pKi 10.5 – 10.9 [13,32]
pancreatic polypeptide {Sp: Rat} Peptide Mm Full agonist 10.7 pKi 30
pKi 10.7 [30]
pancreatic polypeptide {Sp: Human} Peptide Mm Full agonist 10.6 pKi 30
pKi 10.6 [30]
pancreatic polypeptide {Sp: Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Rn Full agonist 10.3 – 10.8 pKi 13,21,32
pKi 10.3 – 10.8 [13,21,32]
pancreatic polypeptide {Sp: Bovine} Peptide Click here for species-specific activity table Rn Full agonist 10.2 – 10.7 pKi 13,32
pKi 10.2 – 10.7 [13,32]
PP-(2-36) (human) Peptide Rn Full agonist 10.4 pKi 32
pKi 10.4 [32]
[Leu31,Pro34]PYY (human) Peptide Click here for species-specific activity table Rn Full agonist 10.2 pKi 13
pKi 10.2 [13]
pancreatic polypeptide {Sp: Rat} Peptide Click here for species-specific activity table Hs Full agonist 10.0 pKi 30
pKi 10.0 [30]
GR231118 Peptide Hs Full agonist 9.8 pKi 30
pKi 9.8 [30]
GR231118 Peptide Mm Full agonist 9.8 pKi 30
pKi 9.8 [30]
pancreatic polypeptide {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Full agonist 8.7 – 10.9 pKi 3,20,30,34
pKi 8.7 – 10.9 [3,20,30,34]
[Leu31,Pro34]NPY Peptide Click here for species-specific activity table Rn Full agonist 8.3 – 10.7 pKi 13,21,32
pKi 8.3 – 10.7 [13,21,32]
pKi 8.3 [32]
[Pro34]PYY (human) Peptide Mm Full agonist 9.5 pKi 30
pKi 9.5 [30]
[Ile31,Gln34]PP (human) Peptide Rn Full agonist 9.2 pKi 32
pKi 9.2 [32]
PP-(13-36) (human) Peptide Rn Full agonist 9.0 pKi 32
pKi 9.0 [32]
[Pro34]PYY (human) Peptide Click here for species-specific activity table Hs Full agonist 8.9 pKi 30
pKi 8.9 [30]
peptide YY {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Full agonist 8.8 pKi 20
pKi 8.8 [20]
NPY {Sp: Pig} Peptide Click here for species-specific activity table Rn Full agonist 8.7 pKi 13
pKi 8.7 [13]
[Pro34]PYY (human) Peptide Rn Full agonist 8.6 pKi 32
pKi 8.6 [32]
PP-(20-36) (human) Peptide Rn Full agonist 8.1 pKi 32
pKi 8.1 [32]
neuropeptide Y {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Full agonist 8.0 pKi 20
pKi 8.0 [20]
NPY-(2-36) Peptide Click here for species-specific activity table Rn Full agonist 7.9 pKi 13
pKi 7.9 [13]
NPY-(3-36) (pig) Peptide Click here for species-specific activity table Rn Full agonist 7.7 pKi 13
pKi 7.7 [13]
[Leu31,Pro34]NPY Peptide Click here for species-specific activity table Hs Full agonist 7.7 pKi 20
pKi 7.7 [20]
neuropeptide Y {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Rn Full agonist 6.4 – 8.8 pKi 13,32
pKi 6.4 – 8.8 [13,32]
pKi 6.4 [32]
PYY-(3-36) {Sp: Human} Peptide Click here for species-specific activity table Rn Full agonist 7.6 pKi 13
pKi 7.6 [13]
NPY-(2-36) (pig) Peptide Click here for species-specific activity table Hs Full agonist 7.4 pKi 20
pKi 7.4 [20]
peptide YY {Sp: Mouse, Rat, Pig} Peptide Click here for species-specific activity table Rn Full agonist 6.3 – 8.5 pKi 13,32
pKi 6.3 – 8.5 [13,32]
pKi 6.3 [32]
NPY-(13-36) (pig) Peptide Click here for species-specific activity table Rn Full agonist 6.3 – 8.2 pKi 13,32
pKi 6.3 – 8.2 [13,32]
NPY-(13-36) (pig) Peptide Click here for species-specific activity table Hs Full agonist 6.9 pKi 20
pKi 6.9 [20]
PYY-(13-36) (mouse, rat, pig) Peptide Click here for species-specific activity table Rn Full agonist 6.2 – 7.5 pKi 13,32
pKi 7.5 [13]
pKi 6.2 [32]
peptide YY {Sp: Human} Peptide Click here for species-specific activity table Rn Full agonist 6.4 pKi 32
pKi 6.4 [32]
PYY-(3-36) {Sp: Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Rn Full agonist 6.2 pKi 32
pKi 6.2 [32]
GR231118 Peptide Click here for species-specific activity table Rn Full agonist 9.5 pIC50 10
pIC50 9.5 [10]
[Leu31,Pro34]NPY Peptide Mm Full agonist 8.4 – 9.5 pIC50 15
pIC50 8.4 – 9.5 [15]
pancreatic polypeptide {Sp: Bovine} Peptide Hs Full agonist 8.6 pIC50 34
pIC50 8.6 [34]
[Leu31,Pro34]NPY (pig) Peptide Click here for species-specific activity table Rn Full agonist 8.4 pIC50 10
pIC50 8.4 [10]
[Leu31,Pro34]PYY (pig) Peptide Click here for species-specific activity table Rn Full agonist 8.0 pIC50 10
pIC50 8.0 [10]
peptide YY {Sp: Mouse, Rat, Pig} Peptide Ligand is endogenous in the given species Mm Full agonist 6.3 – 8.5 pIC50 15
pIC50 6.3 – 8.5 [15]
NPY-(2-36) Peptide Mm Full agonist 5.6 – 7.1 pIC50 15
pIC50 5.6 – 7.1 [15]
[Ala31,Aib32]NPY (pig) Peptide Click here for species-specific activity table Hs Full agonist 6.0 pIC50 6
pIC50 6.0 [6]
View species-specific agonist tables
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GR231118 Peptide Click here for species-specific activity table Rn Antagonist 10.8 pKi 13
pKi 10.8 [13]
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(S)-VU0637120 Small molecule or natural product Hs Negative 5.6 pIC50 27
pIC50 5.6 (IC50 2.7x10-6 M) [27]
Description: Determined in vitro as modulator-induced decrease in Y4 receptor activation by pancreatic polypeptide
tert-butylphenoxycyclohexanol Small molecule or natural product Hs Positive - - 28
[28]
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family Adenylyl cyclase inhibition
References:  22,31-32
Secondary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  22
Tissue Distribution Click here for help
Colon, small intestine, pancreas, prostate.
Species:  Human
Technique:  Northern blotting.
References:  20
Proximal and distal colon.
Species:  Rat
Technique:  RT-PCR.
References:  11
Brain: hypothalamus, hippocampus, brainstem.
Species:  Rat
Technique:  in situ hybridisation.
References:  23
CNS: dorsal vagal complex.
Species:  Rat
Technique:  in situ hybridisation.
References:  18
Aorta, tail artery, hypothalamus, femoral artery, pulmonary artery, renal artery.
Species:  Rat
Technique:  RT-PCR.
References:  4
Large and small intestine (epithelial and nonepithelial tissue).
Species:  Rat
Technique:  RT-PCR.
References:  14
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of cAMP levels in LMTK- cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  LMTK- cells.
Response measured:  Inhibition of cAMP accumulation.
References:  3,32
Measurement of Ca2+ levels in LMTK- cells transfected with the human Y4 reeptor.
Species:  Human
Tissue:  LMTK- cells.
Response measured:  Stimulation of Ca2+ accumulation.
References:  3
Measurement of cAMP levels in HEK 293 cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  31
Measurement of cAMP levels in CHO cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Inhibition of cAMP accumulation.
References:  20
Physiological Functions Click here for help
Reduced appetite and food intake.
Species:  Human
Tissue:  In vivo.
References:  5
Modulation of food intake.
Species:  Mouse
Tissue:  In vivo.
References:  1
Contraction.
Species:  Rat
Tissue:  Colon.
References:  12,24
Stimulation of LH release.
Species:  Rat
Tissue:  In vivo.
References:  16-17,25
Inhibition of arterial neurogenic vasoconstriction.
Species:  Rat
Tissue:  Tail artery, renal artery, femoral artery.
References:  4
Inhibition of electrogenic ion transport.
Species:  Human
Tissue:  Isolated descending colon.
References:  8
Inhibition of electrogenic ion transport.
Species:  Mouse
Tissue:  Colonic mucosal preparaions.
References:  7,30
Physiological Consequences of Altering Gene Expression Click here for help
Y4 receptor knockout mice exhibit an increase in water consumption during the dark phase.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  33
Y4 receptor knockout ob/ob mice exhibit increased fertility compared to ob/ob mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  26
Y4 receptor knockout mice exhibit reduced vasoconstrictor and vagal inhibitory activity.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  29
Y4 receptor knockout mice do not exhibit agonist-induced inhibition of food intake, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  2
Colonic mucosa from Y4 receptor knockout mice does not exhibit the agonist-induced decrease in ion transport as seen in wild-type tissues.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  30
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005452 abnormal adipose tissue amount PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0002896 abnormal bone mineralization PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0003795 abnormal bone structure PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0000662 abnormal branching of the mammary ductal tree PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000130 abnormal cancellous bone morphology PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005180 abnormal circulating testosterone level PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001422 abnormal drinking behavior PMID: 16364461 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001927 abnormal estrous cycle PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0005334 abnormal fat pad morphology PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002161 abnormal fertility/fecundity PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0005449 abnormal food intake PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0003953 abnormal hormone level PMID: 17272395 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002786 abnormal Leydig cell morphology PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0006269 abnormal mammary gland growth during pregnancy PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0005006 abnormal osteoblast physiology PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000057 abnormal osteogenesis PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001131 abnormal ovarian follicle morphology PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002673 abnormal sperm number PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001142 abnormal vagina opening PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001262 decreased body weight PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001262 decreased body weight PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0001262 decreased body weight PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001780 decreased brown adipose tissue amount PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0002727 decreased circulating insulin level PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0005668 decreased circulating leptin level PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000135 decreased cortical bone thickness PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0003910 decreased eating behavior PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0004989 decreased osteoblast cell number PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001783 decreased white adipose tissue amount PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001783 decreased white adipose tissue amount PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0001783 decreased white adipose tissue amount PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001353 increased aggression towards mice PMID: 12000791 
Lep+|Lepob|Ppyr1tm1.1Hhz Lepob/Lep+,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001260 increased body weight PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0009347 increased cancellous bone thickness PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001745 increased circulating corticosterone level PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0004702 increased circulating insulin-like growth factor I level PMID: 17272395 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0003911 increased drinking behavior PMID: 16364461 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0003909 increased eating behavior PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0005137 increased growth hormone level PMID: 17272395 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0004909 increased seminal vesicle weight PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005455 increased susceptibility to weight gain PMID: 12000791 
Lep+|Lepob|Ppyr1tm1.1Hhz Lepob/Lep+,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0000008 increased white adipose tissue amount PMID: 12000791 
Ppyr1tm1Hhz Ppyr1tm1Hhz/Ppyr1tm1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0002169 no abnormal phenotype detected PMID: 19121371 
General Comments
For a review on NPY receptor knockout mice see [19].

References

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