Plasmodium falciparum hexose transporter | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum hexose transporter

Target id: 3069

Nomenclature: Plasmodium falciparum hexose transporter

Abbreviated Name: PfHT

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 504 HT hexose transporter
Database Links
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
TCMDC-125163 PfK1 Parasite growth inhibition assay - - 6.0 pEC50 1
pEC50 6.0 (EC50 9.7x10-7 M) SYBR Green I assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
TCMDC-125163 Pf3D7 Parasite growth inhibition assay - - 5.8 pEC50 1
pEC50 5.8 (EC50 1.4x10-6 M) SYBR Green I assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
The P. falciparum hexose transporter (PfHT) mediates glucose uptake, an essential process because the intraerythrocytic stages of the parasite's lifecycle are dependent upon host glucose for energy [2]. PfHT is a member of the SLC2 family of hexose and sugar alcohol transporters but is highly divergent in sequence from all human orthologs, with GLUT1 the most closely related human ortholog, sharing only 28% amino acid identity with PfHT [1].
PfHT shows promise as a target for antimalarial drug development with a focus on identifying compounds that inhibit the parasite permease without impairing function of human SLC2 transporters.


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1. Ortiz D, Guiguemde WA, Johnson A, Elya C, Anderson J, Clark J, Connelly M, Yang L, Min J, Sato Y et al.. (2015) Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds. PLoS ONE, 10 (4): e0123598. [PMID:25894322]

2. Woodrow CJ, Penny JI, Krishna S. (1999) Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter. J. Biol. Chem., 274 (11): 7272-7. [PMID:10066789]

How to cite this page

Antimalarial targets: Plasmodium falciparum hexose transporter. Last modified on 26/03/2019. Accessed on 11/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY,