Plasmodium falciparum threonine--tRNA ligase | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum threonine--tRNA ligase

Target id: 3058

Nomenclature: Plasmodium falciparum threonine--tRNA ligase

Abbreviated Name: PfThrRS

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 1013 ThrRS threonine--tRNA ligase
Previous and Unofficial Names
Plasmodium falciparum threoninyl-tRNA synthetase
Database Links
UniProtKB
Malaria Pharmacology Comments
The aminoacyl-tRNA synthetases are emerging targets for antimalarial agents [1]. Although sharing a common tRNA esterification catalytic activity, these proteins are structurally diverse and physiologically distinct enzymes.

References

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1. Manickam Y, Chaturvedi R, Babbar P, Malhotra N, Jain V, Sharma A. (2018) Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum. Drug Discov. Today, 23 (6): 1233-1240. [PMID:29408369]

How to cite this page

Antimalarial targets: Plasmodium falciparum threonine--tRNA ligase. Last modified on 12/06/2019. Accessed on 18/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3058.