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Target id: 3056
Nomenclature: Plasmodium falciparum proline--tRNA ligase
Abbreviated Name: PfPRS
Family: Antimalarial targets
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Plasmodium falciparum 3D7 | - | 746 | PRS | proline--tRNA ligase |
Previous and Unofficial Names ![]() |
Plasmodium falciparum prolyl-tRNA synthetase | PfPRORS |
Database Links ![]() |
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ChEMBL Target | CHEMBL3301560 (Pf3D7) |
PlasmoDB | PF3D7_1213800 (Pf3D7) |
SynPHARM | 85927 (in complex with halofuginone) |
UniProtKB | Q8I5R7 (Pf3D7) |
Selected 3D Structures ![]() |
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Whole Organism Assay Data Linked to This Target | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Malaria Pharmacology Comments |
The aminoacyl-tRNA synthetases are emerging targets for antimalarial agents [4]. Although sharing a common tRNA esterification catalytic activity, these proteins are structurally diverse and physiologically distinct enzymes. |
1. Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA et al.. (2015) The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med, 7 (288): 288ra77. [PMID:25995223]
2. Jain V, Kikuchi H, Oshima Y, Sharma A, Yogavel M. (2014) Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase. J. Struct. Funct. Genomics, 15 (4): 181-90. [PMID:25047712]
3. Jain V, Yogavel M, Oshima Y, Kikuchi H, Touquet B, Hakimi MA, Sharma A. (2015) Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis. Structure, 23 (5): 819-829. [PMID:25817387]
4. Manickam Y, Chaturvedi R, Babbar P, Malhotra N, Jain V, Sharma A. (2018) Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum. Drug Discov. Today, 23 (6): 1233-1240. [PMID:29408369]
Antimalarial targets: Plasmodium falciparum proline--tRNA ligase. Last modified on 12/06/2019. Accessed on 19/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3056.