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dual oxidase 2

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Target id: 2999

Nomenclature: dual oxidase 2

Abbreviated Name: DUOX2

Family: NADPH oxidases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 1548 15q21.1 DUOX2 dual oxidase 2 2-3
Mouse - 1545 2 E5 Duox2 dual oxidase 2
Rat 7 1517 3q35 Duox2 dual oxidase 2
Previous and Unofficial Names Click here for help
dual oxidase-like domains 2 | LNOX2 | NADPH oxidase/peroxidase DUOX2 | NADPH thyroid oxidase 2 | P138(TOX) | THOX2
Database Links Click here for help
Alphafold
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.6.3.1
Description Reaction Reference
Generation of hydrogen peroxide NAD(P)H + O2 <=> NAD(P)+ + H2O2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
NSC 780521 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.1 pIC50 6
pIC50 6.1 (IC50 7.73x10-7 M) [6]
Description: Inhibition of hydrogen peroxide formation in HEK293 cells expressing DUOX2/DUOXA2.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0019221 cytokine-mediated signaling pathway IDA
Tissue Distribution Click here for help
DUOX2 is the main DUOX isoform expressed in the gastrointestinal tract- expressed most prominently within the colon epithelium at the tip of intestinal villi and within rectal glands.
Species:  Human
Technique: 
References:  4-5,7
Gene Expression and Pathophysiology Comments
Missense mutations in DUOX2 that cause diminished enzymatic function have been identified in patients with hypothyroidism [1], confirming the role of this enzyme isoform in thyroid hormone production.

References

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1. De Deken X, Corvilain B, Dumont JE, Miot F. (2014) Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling. Antioxid Redox Signal, 20 (17): 2776-93. [PMID:24161126]

2. De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F. (2000) Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem, 275 (30): 23227-33. [PMID:10806195]

3. Dupuy C, Ohayon R, Valent A, Noël-Hudson MS, Dème D, Virion A. (1999) Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem, 274 (52): 37265-9. [PMID:10601291]

4. El Hassani RA, Benfares N, Caillou B, Talbot M, Sabourin JC, Belotte V, Morand S, Gnidehou S, Agnandji D, Ohayon R et al.. (2005) Dual oxidase2 is expressed all along the digestive tract. Am J Physiol Gastrointest Liver Physiol, 288 (5): G933-42. [PMID:15591162]

5. Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL. (2003) Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J, 17 (11): 1502-4. [PMID:12824283]

6. Lu J, Risbood P, Kane Jr CT, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A et al.. (2017) Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases. Biochem Pharmacol, 143: 25-38. [PMID:28709950]

7. Sommer F, Bäckhed F. (2015) The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium. Mucosal Immunol, 8 (2): 372-9. [PMID:25160818]

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