Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	160	8q21.11	LY96	lymphocyte antigen 96
Mouse	-	160	1 A3	Ly96	lymphocyte antigen 96
Rat	-	160	5	Ly96	lymphocyte antigen 96

Previous and Unofficial Names

LPS co-receptor MD-2 | myeloid differentiation factor-2 | ESOP-1

Database Links
Alphafold	Q9Y6Y9 (Hs), Q9JHF9 (Mm)
ChEMBL Target	CHEMBL2375202 (Hs), CHEMBL2384895 (Mm)
Ensembl Gene	ENSG00000154589 (Hs), ENSMUSG00000025779 (Mm), ENSRNOG00000067966 (Rn)
Entrez Gene	23643 (Hs), 17087 (Mm), 448830 (Rn)
Human Protein Atlas	ENSG00000154589 (Hs)
KEGG Gene	hsa:23643 (Hs), mmu:17087 (Mm), rno:448830 (Rn)
OMIM	605243 (Hs)
Pharos	Q9Y6Y9 (Hs)
RefSeq Nucleotide	NM_015364 (Hs), NM_016923 (Mm), NM_001024279 (Rn)
RefSeq Protein	NP_056179 (Hs), NP_058619 (Mm), NP_001019450 (Rn)
UniProtKB	Q9Y6Y9 (Hs), Q9JHF9 (Mm)
Wikipedia	LY96 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference L6H21 Hs Inhibition 4.5 pKd 2 ⤷ pKd 4.5 (Kd 3.3x10-5 M) [2]

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference neoceptin-3 Hs Binding - - 3 ⤷ [3]

Immunopharmacology Comments

LY96 (MD2) is a binding partner of Toll-like receptor 4 (TLR4), required to initiate an innate immune response to bacterial lipopolysaccharide (LPS). The signaling complex also contains CD14 co-receptor [1]. LY96 is an important therapeutic target for inflammatory disorders.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

General Comments
ChEMBL target CHEMBL3038513 is the complex of human LY96 and Toll-like receptor 4 (TLR4).