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leucine rich repeat and Ig domain containing 1

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Target id: 2882

Nomenclature: leucine rich repeat and Ig domain containing 1

Abbreviated Name: LINGO1

Family: Reticulons and associated proteins

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 620 15q24.3 LINGO1 leucine rich repeat and Ig domain containing 1
Mouse 1 614 9 B Lingo1 leucine rich repeat and Ig domain containing 1
Rat 1 620 8q24 Lingo1 leucine rich repeat and Ig domain containing 1
Gene and Protein Information Comments
The table above shows details of the longest variant (variant 1) of isoform a of the human LINGO1 protein. Many other shorter variants are described (variants of isoform b).
Previous and Unofficial Names Click here for help
LERN1 | LINGO-1
Database Links Click here for help
Alphafold Q96FE5 (Hs), Q9D1T0 (Mm)
CATH/Gene3D 2.60.40.10, 3.80.10.10
ChEMBL Target CHEMBL3712965 (Hs)
Ensembl Gene ENSG00000169783 (Hs), ENSMUSG00000049556 (Mm), ENSRNOG00000017193 (Rn)
Entrez Gene 84894 (Hs), 235402 (Mm), 315691 (Rn)
Human Protein Atlas ENSG00000169783 (Hs)
KEGG Gene hsa:84894 (Hs), mmu:235402 (Mm), rno:315691 (Rn)
OMIM 609791 (Hs)
Pharos Q96FE5 (Hs)
RefSeq Nucleotide NM_032808 (Hs), NM_001311076 (Mm), NM_001100722 (Rn)
RefSeq Protein NP_116197 (Hs), NP_001298005 (Mm), NP_001094192 (Rn)
UniProtKB Q96FE5 (Hs), Q9D1T0 (Mm)
Wikipedia LINGO1 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
opicinumab Peptide Primary target of this compound Hs Binding >10.0 pEC50 3
⤷ pEC50 >10.0 (EC50 <1.1x10-10 M) [3]
Description: Binding to LINGO1 by Fab of the antibody.
General Comments
LINGO1 is a large membrane associated protein which is important for the function of the nervous system. It is an essential negative regulator of myelination, and is implicated in the inhibition of axon regeneration [1-2,4]. Interactions with a variety of different co-factors and co-receptors facilitates LINGO1 effects on the regulation of biological processes involved in neuronal survival, axon regeneration, oligodendrocyte differentiation, or myelination processes in the CNS.

References

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1. Andrews JL, Fernandez-Enright F. (2015) A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders. Neurosci Biobehav Rev, 56: 97-114. [PMID:26143511]

2. Jepson S, Vought B, Gross CH, Gan L, Austen D, Frantz JD, Zwahlen J, Lowe D, Markland W, Krauss R. (2012) LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions. J Biol Chem, 287 (26): 22184-95. [PMID:22514275]

3. Mi S, Pepinsky B, Graff C. (2011) Composition comprising antibodies to LINGO or fragments thereof. Patent number: US8058406 B2. Assignee: Biogen Idec Ma Inc.. Priority date: 09/11/2016. Publication date: 15/11/2011.

4. Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A, Zhong X, Presman E, Benard S, Kelleher K et al.. (2006) The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J Biol Chem, 281 (47): 36378-90. [PMID:17005555]

How to cite this page

Reticulons and associated proteins: leucine rich repeat and Ig domain containing 1. Last modified on 23/11/2015. Accessed on 29/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2882.