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egl-9 family hypoxia inducible factor 3

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Target id: 2834

Nomenclature: egl-9 family hypoxia inducible factor 3

Abbreviated Name: PHD3

Family: Prolyl hydroxylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 239 14q13.1 EGLN3 egl-9 family hypoxia inducible factor 3
Mouse - 239 12 C1 Egln3 egl-9 family hypoxia-inducible factor 3
Rat - 239 6q23 Egln3 egl-9 family hypoxia-inducible factor 3
Previous and Unofficial Names Click here for help
EGL nine (C.elegans) homolog 3 | HIF prolyl hydroxylase 3 | HIFPH3 | egl-9 family hypoxia-inducible factor 3
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 6ee [PMID: 22364528] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.5 pIC50 2
pIC50 8.5 (IC50 3.5x10-9 M) [2]
molidustat Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 4.9x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


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1. Thede K et al.. (2014) Substituted dihydropyrazolones for treating cardiovascular and hematological diseases. Patent number: US8653111 B2. Assignee: Bayer Intellectual Property Gmbh.. Priority date: 26/10/2006. Publication date: 18/02/2014.

2. Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R et al.. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem, 55 (7): 2945-59. [PMID:22364528]

How to cite this page

Prolyl hydroxylases: egl-9 family hypoxia inducible factor 3. Last modified on 17/07/2017. Accessed on 28/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY,