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egl-9 family hypoxia inducible factor 3

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Target id: 2834

Nomenclature: egl-9 family hypoxia inducible factor 3

Abbreviated Name: PHD3

Family: Prolyl hydroxylases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 239 14q13.1 EGLN3 egl-9 family hypoxia inducible factor 3
Mouse - 239 12 C1 Egln3 egl-9 family hypoxia-inducible factor 3
Rat - 239 6q23 Egln3 egl-9 family hypoxia-inducible factor 3
Previous and Unofficial Names Click here for help
EGL nine (C.elegans) homolog 3 | HIF prolyl hydroxylase 3 | HIFPH3 | egl-9 family hypoxia-inducible factor 3
Database Links Click here for help
Alphafold Q9H6Z9 (Hs), Q91UZ4 (Mm), Q62630 (Rn)
BRENDA 1.14.11.29
ChEMBL Target CHEMBL5705 (Hs)
Ensembl Gene ENSG00000129521 (Hs), ENSMUSG00000035105 (Mm), ENSRNOG00000005053 (Rn)
Entrez Gene 112399 (Hs), 112407 (Mm), 54702 (Rn)
Human Protein Atlas ENSG00000129521 (Hs)
KEGG Enzyme 1.14.11.29
KEGG Gene hsa:112399 (Hs), mmu:112407 (Mm), rno:54702 (Rn)
OMIM 606426 (Hs)
Pharos Q9H6Z9 (Hs)
RefSeq Nucleotide NM_022073 (Hs), NM_028133 (Mm), NM_019371 (Rn)
RefSeq Protein NP_071356 (Hs), NP_082409 (Mm), NP_062244 (Rn)
UniProtKB Q9H6Z9 (Hs), Q91UZ4 (Mm), Q62630 (Rn)
Wikipedia EGLN3 (Hs)
Enzyme Reaction Click here for help
EC Number: 1.14.11.29

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 6ee [PMID: 22364528] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.5 pIC50 2
⤷ pIC50 8.5 (IC50 3.5x10-9 M) [2]
molidustat Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.3 pIC50 1
⤷ pIC50 6.3 (IC50 4.9x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling

References

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1. Thede K et al.. (2014) Substituted dihydropyrazolones for treating cardiovascular and hematological diseases. Patent number: US8653111 B2. Assignee: Bayer Intellectual Property Gmbh.. Priority date: 26/10/2006. Publication date: 18/02/2014.

2. Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R et al.. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem, 55 (7): 2945-59. [PMID:22364528]

How to cite this page

Prolyl hydroxylases: egl-9 family hypoxia inducible factor 3. Last modified on 17/07/2017. Accessed on 17/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2834.