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CD80

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Target id: 2744

Nomenclature: CD80

Family: Other immune checkpoint proteins, CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 288 3q13.33 CD80 CD80 molecule
Mouse 1 306 16 26.86 cM Cd80 CD80 antigen
Rat - 321 11q21 Cd80 Cd80 molecule
Previous and Unofficial Names Click here for help
B-lymphocyte activation antigen B7 | CD28LG | CD80 antigen
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
CD80 (B7-1) is expressed on dendritic cells and activated B cells and monocytes. It is required to provide a costimulatory signal necessary for T cell activation and survival. CD80 works in concert with CD86 to prime T cells. CD80 binds CD28 and CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
monocyte (CL:0000576)
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Immuno Cell Type:  T cells
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production NAS
GO:0032743 positive regulation of interleukin-2 production NAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 4 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001618 virus receptor activity IEA
Immuno Disease Associations
Disease Name:  Allograft rejection
Disease Synonyms:  no synonynms
Comment:  CD80 is a primary target of the approved anti-rejection drug belatacept.
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  CD80 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  3
General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

References

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1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]

2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med, 174 (3): 561-9. [PMID:1714933]

3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]

How to cite this page

CD molecules: CD80. Last modified on 28/06/2022. Accessed on 10/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2744.