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CD80

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Target id: 2744

Nomenclature: CD80

Family: Other immune checkpoint proteins, CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 288 3q13.33 CD80 CD80 molecule
Mouse 1 306 16 26.86 cM Cd80 CD80 antigen
Rat - 321 11q21 Cd80 Cd80 molecule
Previous and Unofficial Names Click here for help
B-lymphocyte activation antigen B7 | CD28LG | CD80 antigen
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
abatacept Peptide Approved drug Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition ~7.9 pKd 2-3
pKd ~7.9 (Kd ~1.2x10-8 M) [2-3]
Description: Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept.
belatacept Peptide Approved drug Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition - - 1
[1]
Description: IC50= 0.009µg/mL
Immunopharmacology Comments
CD80 (B7-1) is expressed on dendritic cells and activated B cells and monocytes. It is required to provide a costimulatory signal necessary for T cell activation and survival. CD80 works in concert with CD86 to prime T cells. CD80 binds CD28 and CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   monocyte (CL:0000576)
macrophage (CL:0000235)
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Immuno Cell Type:  T cells
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 5 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
GO:0046641 positive regulation of alpha-beta T cell proliferation IDA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
GO:0046641 positive regulation of alpha-beta T cell proliferation IDA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process NAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 5 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
GO:0046641 positive regulation of alpha-beta T cell proliferation IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 5 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045627 positive regulation of T-helper 1 cell differentiation NAS
GO:0046641 positive regulation of alpha-beta T cell proliferation IDA
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001618 virus receptor activity IEA
Immuno Disease Associations
Disease Name:  Allograft rejection
Disease Synonyms:  no synonynms
Comment:  CD80 is a primary target of the approved anti-rejection drug belatacept.
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  CD80 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  3
General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

References

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1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]

2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med., 174 (3): 561-9. [PMID:1714933]

3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]

How to cite this page

Other immune checkpoint proteins: CD80. Last modified on 07/08/2019. Accessed on 24/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2744.