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CECR2 histone acetyl-lysine reader

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Target id: 2733

Nomenclature: CECR2 histone acetyl-lysine reader

Family: Non-enzymatic BRD containing proteins

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1484 22q11.1-q11.21 CECR2 CECR2 histone acetyl-lysine reader
Mouse - 1425 6 F1 Cecr2 CECR2, histone acetyl-lysine reader
Rat - 1437 4q42 Cecr2 CECR2, histone acetyl-lysine reader
Previous and Unofficial Names Click here for help
cat eye syndrome chromosome region, candidate 2 | cat eye syndrome chromosome region | CECR2, histone acetyl-lysine reader | CECR2
Database Links Click here for help
Alphafold Q9BXF3 (Hs)
CATH/Gene3D 1.20.920.10
ChEMBL Target CHEMBL3108639 (Hs)
Ensembl Gene ENSG00000099954 (Hs), ENSMUSG00000071226 (Mm), ENSRNOG00000011566 (Rn)
Entrez Gene 27443 (Hs), 330409 (Mm), 500308 (Rn)
Human Protein Atlas ENSG00000099954 (Hs)
KEGG Gene hsa:27443 (Hs), mmu:330409 (Mm), rno:500308 (Rn)
OMIM 607576 (Hs)
Pharos Q9BXF3 (Hs)
RefSeq Nucleotide NM_001290047 (Hs), NM_001128151 (Mm), NM_001191977 (Rn)
RefSeq Protein NP_001276976 (Hs), NP_001121623 (Mm), NP_001178906 (Rn)
UniProtKB Q9BXF3 (Hs)
Wikipedia CECR2 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
NVS-1 Small molecule or natural product Primary target of this compound Hs Inhibition 7.1 – 7.3 pIC50 2
⤷ pIC50 7.1 – 7.3 (IC50 8x10-8 – 4.7x10-8 M) [2]
Description: Measured using AlphaScreen or ITC assays.
compound 50 [PMID: 24313754] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.8 pIC50 1
⤷ pIC50 6.8 (IC50 1.58x10-7 M) [1]

References

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1. Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, Yapp C, Philpott M, Martin SJ, Felletar I et al.. (2014) [1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains. J Med Chem, 57 (2): 462-76. [PMID:24313754]

2. SGC. NVS-CECR2-1 A chemical probe for CECR2. Accessed on 11/12/2015. Modified on 04/08/2023. thesgc.org, https://www.thesgc.org/chemical-probes/NVS-CECR2-1

How to cite this page

Non-enzymatic BRD containing proteins: CECR2 histone acetyl-lysine reader. Last modified on 27/03/2019. Accessed on 19/09/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2733.