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bromodomain PHD finger transcription factor

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Target id: 2723

Nomenclature: bromodomain PHD finger transcription factor

Family: Non-enzymatic BRD containing proteins

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 3046 17q24.2 BPTF bromodomain PHD finger transcription factor
Mouse - 2921 11 E1 Bptf bromodomain PHD finger transcription factor
Rat - - 10q32.1 Bptf bromodomain PHD finger transcription factor
Previous and Unofficial Names Click here for help
FAC1 | FALZ
Database Links Click here for help
Alphafold Q12830 (Hs)
CATH/Gene3D 1.20.920.10, 3.30.40.10
ChEMBL Target CHEMBL3085621 (Hs)
Ensembl Gene ENSG00000171634 (Hs), ENSMUSG00000040481 (Mm), ENSRNOG00000047296 (Rn)
Entrez Gene 2186 (Hs), 207165 (Mm), 303617 (Rn)
Human Protein Atlas ENSG00000171634 (Hs)
KEGG Gene hsa:2186 (Hs), mmu:207165 (Mm), rno:303617 (Rn)
OMIM 601819 (Hs)
Pharos Q12830 (Hs)
RefSeq Nucleotide NM_004459 (Hs), NM_176850 (Mm)
RefSeq Protein NP_004450 (Hs), NP_789820 (Mm)
UniProtKB Q12830 (Hs)
Wikipedia BPTF (Hs)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
MS363 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 5.8 pKi 1
⤷ pKi 5.8 (Ki 1.62x10-6 M) [1]

References

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1. Zhang G, Plotnikov AN, Rusinova E, Shen T, Morohashi K, Joshua J, Zeng L, Mujtaba S, Ohlmeyer M, Zhou MM. (2013) Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem, 56 (22): 9251-64. [PMID:24144283]

How to cite this page

Non-enzymatic BRD containing proteins: bromodomain PHD finger transcription factor. Last modified on 13/02/2017. Accessed on 19/09/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2723.