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bromodomain adjacent to zinc finger domain 2A

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Target id: 2721

Nomenclature: bromodomain adjacent to zinc finger domain 2A

Family: Non-enzymatic BRD containing proteins

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1905 12q13.3 BAZ2A bromodomain adjacent to zinc finger domain 2A
Mouse - 1887 10 D3 Baz2a bromodomain adjacent to zinc finger domain, 2A
Rat - 1691 7q11 Baz2a bromodomain adjacent to zinc finger domain, 2A
Previous and Unofficial Names Click here for help
TIP5 | WALp3 | TTF-I interacting peptide 5 | bromodomain adjacent to zinc finger domain, 2A | bromodomain adjacent to zinc finger domain
Database Links Click here for help
Alphafold Q9UIF9 (Hs)
CATH/Gene3D 1.20.920.10, 3.30.40.10
ChEMBL Target CHEMBL3108642 (Hs)
Ensembl Gene ENSG00000076108 (Hs), ENSMUSG00000040054 (Mm), ENSRNOG00000053881 (Rn)
Entrez Gene 11176 (Hs), 116848 (Mm), 304601 (Rn)
Human Protein Atlas ENSG00000076108 (Hs)
KEGG Gene hsa:11176 (Hs), mmu:116848 (Mm), rno:304601 (Rn)
OMIM 605682 (Hs)
Pharos Q9UIF9 (Hs)
RefSeq Nucleotide NM_013449 (Hs), NM_054078 (Mm), NM_001107158 (Rn)
RefSeq Protein NP_038477 (Hs), NP_473419 (Mm), NP_001100628 (Rn)
UniProtKB Q9UIF9 (Hs)
Wikipedia BAZ2A (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BAZ2-ICR Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.0 pKd 1
⤷ pKd 7.0 (Kd 1.09x10-7 M) [1]
Description: Isothermal titration calorimetry (ITC) assay
GSK2801 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.6 pKd 2
⤷ pKd 6.6 (Kd 2.57x10-7 M) [2]
Description: Isothermal titration calorimetry (ITC) assay

References

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1. Drouin L, McGrath S, Vidler LR, Chaikuad A, Monteiro O, Tallant C, Philpott M, Rogers C, Fedorov O, Liu M et al.. (2015) Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J Med Chem, 58 (5): 2553-9. [PMID:25719566]

2. SGC. GSK2801: A Selective Chemical Probe for BAZ2B/A bromodomains. Accessed on 03/03/2015. Modified on 04/08/2023. thesgc.org, https://www.thesgc.org/chemical-probes/GSK2801

How to cite this page

Non-enzymatic BRD containing proteins: bromodomain adjacent to zinc finger domain 2A. Last modified on 29/01/2016. Accessed on 19/09/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2721.