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Gene and Protein Information | ||||||
class C G protein-coupled receptor | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 345 | 12p13.1 | GPRC5D | G protein-coupled receptor class C group 5 member D | 2 |
Mouse | 7 | 344 | 6 G1 | Gprc5d | G protein-coupled receptor, family C, group 5, member D | 2 |
Rat | 7 | 332 | 4q43 | Gprc5d | G protein-coupled receptor, class C, group 5, member D |
Previous and Unofficial Names |
RAIG4 | G protein-coupled receptor, class C, group 5, member D | G protein-coupled receptor |
Database Links | |
Alphafold | Q9NZD1 (Hs), Q9JIL6 (Mm) |
ChEMBL Target | CHEMBL4523925 (Hs) |
Ensembl Gene | ENSG00000111291 (Hs), ENSMUSG00000030205 (Mm), ENSRNOG00000008439 (Rn) |
Entrez Gene | 55507 (Hs), 93746 (Mm), 500349 (Rn) |
Human Protein Atlas | ENSG00000111291 (Hs) |
KEGG Gene | hsa:55507 (Hs), mmu:93746 (Mm), rno:500349 (Rn) |
OMIM | 607437 (Hs) |
Pharos | Q9NZD1 (Hs) |
RefSeq Nucleotide | NM_018654 (Hs), NM_053118 (Mm), NM_001109254 (Rn) |
RefSeq Protein | NP_061124 (Hs), NP_444348 (Mm), NP_001102724 (Rn) |
UniProtKB | Q9NZD1 (Hs), Q9JIL6 (Mm) |
Wikipedia | GPRC5D (Hs) |
Download all structure-activity data for this target as a CSV file
Antibodies | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Tissue Distribution | ||||||||
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Expression Datasets | |
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General Comments |
Orphan receptor. Although it shares similarities with the retinoic acid induced genes, there is actually no evidence this gene is induced by retinoic acid. |
1. Attar R, Gaudet F, Tornetta M, Teplyakov A, Mendonca M, Edavettal S, Pillarisetti K, Majewski N, Li Y, Luistro LL III et al.. (2020) Anti-GPRC5D antibodies, bispecific antigen binding molecules that bind GPRC5D and CD3, and uses thereof. Patent number: US10562968B2. Assignee: Janssen Pharmaceutica NV. Priority date: 20/07/2016. Publication date: 07/11/2022.
2. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. (2001) Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim Biophys Acta, 1518: 237-248. [PMID:11311935]
3. Pillarisetti K, Edavettal S, Mendonça M, Li Y, Tornetta M, Babich A, Majewski N, Husovsky M, Reeves D, Walsh E et al.. (2020) A T-cell-redirecting bispecific G-protein-coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma. Blood, 135 (15): 1232-1243. [PMID:32040549]