talquetamab   Click here for help

GtoPdb Ligand ID: 12240

Synonyms: JNJ-64407564 | JNJ64407564 | talquetamab-tgvs | Talvey®
Approved drug
talquetamab is an approved drug (FDA & EMA (2023))
Compound class: Antibody
Comment: Talquetamab (JNJ-64407564) is a humanized, IgG4 bispecific monoclonal antibody that engages the orphan GPCR GPRC5D that's expressed on majority of malignant plasma cells from multiple myeloma (MM) patients and CD3ε on T cells [3]. It has amino acid substitutions in its Fc region to minimise binding to Fcγ receptors and antibody-directed effector functions. The peptide sequences for talquetamab's heavy and light chains are claimed in Janssen's patent US10562968B2 [1]. In preclinical studies talquetamab promoted immune killing of MM cells, including cells from patients with daratumumab-refractory disease [4].
Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA & EMA (2023))
International Nonproprietary Names Click here for help
INN number INN
11173 talquetamab
Synonyms Click here for help
JNJ-64407564 | JNJ64407564 | talquetamab-tgvs | Talvey®
Database Links Click here for help
Specialist databases
GPCRdb Ligand talquetamab
IMGT/mAb-DB 973
Other databases
GtoPdb PubChem SID 473153828
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