Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	335	15q25.1	CTSH	cathepsin H
Mouse	-	333	9 47.4 cM	Ctsh	cathepsin H
Rat	-	333	8q31	Ctsh	cathepsin H

Previous and Unofficial Names

ACC-4 | ACC-5 | cathepsin B3 | cathepsin BA | CPSB

Database Links
Specialist databases
MEROPS	C01.040 (Hs)
Other databases
Alphafold	P09668 (Hs), P49935 (Mm), P00786 (Rn)
BRENDA	3.4.22.16
ChEMBL Target	CHEMBL2225 (Hs), CHEMBL1949491 (Mm), CHEMBL3308952 (Rn)
Ensembl Gene	ENSG00000103811 (Hs), ENSMUSG00000032359 (Mm), ENSRNOG00000014064 (Rn)
Entrez Gene	1512 (Hs), 13036 (Mm), 25425 (Rn)
Human Protein Atlas	ENSG00000103811 (Hs)
KEGG Enzyme	3.4.22.16
KEGG Gene	hsa:1512 (Hs), mmu:13036 (Mm), rno:25425 (Rn)
OMIM	116820 (Hs)
Orphanet	ORPHA371315 (Hs)
Pharos	P09668 (Hs)
RefSeq Nucleotide	NM_004390 (Hs), NM_007801 (Mm), NM_012939 (Rn)
RefSeq Protein	NP_004381 (Hs), NP_031827 (Mm), NP_037071 (Rn)
UniProtKB	P09668 (Hs), P49935 (Mm), P00786 (Rn)
Wikipedia	CTSH (Hs)

Enzyme Reaction
EC Number: 3.4.22.16

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 1b [PMID: 16290936] Hs Inhibition 7.4 pKi 1 ⤷ pKi 7.4 (Ki 4x10-8 M) [1] compound 1e [PMID: 27285276] Hs Inhibition 6.4 pIC50 3 ⤷ pIC50 6.4 (IC50 4.4x10-7 M) [3]

Immunopharmacology Comments

Cathepsin H may act as a pro-granzyme B convertase [2], granzyme B being the most potent proapoptotic cytotoxin of the granule exocytosis pathway of cytotoxic lymphocytes. It is similarly active in NK cells [4]. However, results from cathepsin H-null mice indicate a high degree of functional redundancy in granzyme B maturation, with enzymes other than cathepsin H active in this process. Cathepsins B, H and L have become important therapeutic targets as their proteolytic activity has been implicated in several pathological inflammatory conditions, such as arthritis and periodontitis. Therefore, pharmacological inhibitors of these enzymes are in development as novel therapeutics.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Antigen presentation

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Clinically-Relevant Mutations and Pathophysiology
Disease:  Narcolepsy-cataplexy Synonyms: Cataplexy and narcolepsy [Disease Ontology: DOID:9199] Disease Ontology: DOID:9199 Orphanet: ORPHA2073