Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	300	20q13.33	TNFRSF6B	TNF receptor superfamily member 6b

Previous and Unofficial Names

DCR3 | decoy receptor for Fas ligand | tumor necrosis factor receptor superfamily, member 6b, decoy | tumor necrosis factor receptor superfamily member 6b

Database Links
Alphafold	O95407 (Hs)
Ensembl Gene	ENSG00000243509 (Hs)
Entrez Gene	8771 (Hs)
Human Protein Atlas	ENSG00000243509 (Hs)
KEGG Gene	hsa:8771 (Hs)
OMIM	603361 (Hs)
Pharos	O95407 (Hs)
UniProtKB	O95407 (Hs)
Wikipedia	TNFRSF6B (Hs)

Natural/Endogenous Ligands
LIGHT {Sp: Human}

Immunopharmacology Comments

The protein product of the TNFRSF6B gene, known as decoy receptor 3 (DcR3), is a soluble endogenous receptor for three TNF family peptide ligands, LIGHT, TL1A and Fas ligand. DcR3 competes for ligand binding with death receptors. DcR3 suppresses LIGHT and FAS ligand induced apoptosis and T cell activation, and increases monocyte adhesion to endothelial cells via NF-κB activation [1]. DcR3 binding to TL1A induces angiogenesis [2]. These functions of DcR3 suggest it provides a connection between inflammation and cancer development.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling