TL1A   Click here for help

GtoPdb Ligand ID: 5071

Synonyms: Tumor necrosis factor ligand superfamily member 15, membrane form
Immunopharmacology Ligand
Comment: The TNFSF15 precursor is also cleaved into a soluble form of the ligand. TL1A principally acts as a negative modulator of epithelial cell proliferation (it can induce apoptosis in these cells), and has some anti-angiogenic action.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Tumor necrosis factor superfamily ligands
Synonyms Click here for help
Tumor necrosis factor ligand superfamily member 15, membrane form
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF15 TNF superfamily member 15 Human prepro-tumor necrosis factor ligand superfamily member 15 MGC129934, MGC129935, TL1, TL1A, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, tumor necrosis factor (ligand) superfamily, member 15, tumor necrosis factor superfamily member 15, vascular endothelial cell growth inhibitor, vascular endothelial growth inhibitor-192A, VEGI, VEGI192A
Database Links Click here for help
CATH/Gene3D 2.60.120.40
Ensembl Gene ENSG00000181634 (Hs)
GtoPdb PubChem SID 178101764
Human Protein Atlas ENSG00000181634 (Hs)
UniProtKB O95150 (Hs)
Wikipedia TNFSF15