Quaternary Structure: Complexes

Interleukin-27 receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	636	19p13.12	IL27RA	interleukin 27 receptor subunit alpha
Mouse	1	623	8 C2	Il27ra	interleukin 27 receptor, alpha
Rat	-	-	19q11	Il27ra	interleukin 27 receptor subunit alpha

Previous and Unofficial Names

WSX-1 | cytokine receptor-like 1 | IL-27RA | TCCR | interleukin 27 receptor, alpha | interleukin 27 receptor

Database Links
Alphafold	Q6UWB1 (Hs), O70394 (Mm)
CATH/Gene3D	2.60.40.10
Ensembl Gene	ENSG00000104998 (Hs), ENSMUSG00000005465 (Mm), ENSRNOG00000005729 (Rn), ENSRNOG00000005747 (Rn)
Human Protein Atlas	ENSG00000104998 (Hs)
Pharos	Q6UWB1 (Hs)
UniProtKB	Q6UWB1 (Hs), O70394 (Mm)
Wikipedia	IL27RA (Hs)

Immunopharmacology Comments

This is the ligand binding subunit of the IL-27 receptor heterodimer, a complex with IL6ST (signal transducing subunit).

Immuno Process Associations

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 2 GO processes, IEA only GO:0042104 positive regulation of activated T cell proliferation IBA click arrow to show/hide IEA associations GO:2000408 negative regulation of T cell extravasation IEA

Immuno Process:  Inflammation GO Annotations:  Associated to 2 GO processes, IEA only click arrow to show/hide IEA associations GO:0048302 regulation of isotype switching to IgG isotypes IEA GO:2000408 negative regulation of T cell extravasation IEA

Immuno Process:  T cell (activation) GO Annotations:  Associated to 4 GO processes, IEA only GO:0042104 positive regulation of activated T cell proliferation IBA click arrow to show/hide IEA associations GO:0002827 positive regulation of T-helper 1 type immune response IEA GO:0048302 regulation of isotype switching to IgG isotypes IEA GO:2000317 negative regulation of T-helper 17 type immune response IEA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 3 GO processes, IEA only click arrow to show/hide IEA associations GO:0002827 positive regulation of T-helper 1 type immune response IEA GO:0048302 regulation of isotype switching to IgG isotypes IEA GO:2000317 negative regulation of T-helper 17 type immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 6 GO processes, IEA only GO:0042104 positive regulation of activated T cell proliferation IBA click arrow to show/hide IEA associations GO:0002827 positive regulation of T-helper 1 type immune response IEA GO:0002829 negative regulation of type 2 immune response IEA GO:0048302 regulation of isotype switching to IgG isotypes IEA GO:2000317 negative regulation of T-helper 17 type immune response IEA GO:2000408 negative regulation of T cell extravasation IEA

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0048302 regulation of isotype switching to IgG isotypes IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 7 GO processes, IEA only GO:0004896 cytokine receptor activity IBA GO:0019221 cytokine-mediated signaling pathway IBA GO:0045509 interleukin-27 receptor activity IBA click arrow to show/hide IEA associations GO:0032700 negative regulation of interleukin-17 production IEA GO:0032715 negative regulation of interleukin-6 production IEA GO:0032720 negative regulation of tumor necrosis factor production IEA GO:0032729 positive regulation of type II interferon production IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 2 GO processes, IEA only GO:0042104 positive regulation of activated T cell proliferation IBA click arrow to show/hide IEA associations GO:0048302 regulation of isotype switching to IgG isotypes IEA

Physiological Consequences of Altering Gene Expression
MIce lacking Il27ra expression by their Treg cells develop more severe experimental autoimmune encephalomyelitis (EAE) than wild type mice, indicating that IL-27 is important for Treg function and control of autoimmunity. Species:  Mouse Tissue:  T regulatory cells. Technique:  References:  1