Quaternary Structure: Complexes

Interleukin-27 receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	636	19p13.12	IL27RA	interleukin 27 receptor subunit alpha
Mouse	1	623	8 C2	Il27ra	interleukin 27 receptor, alpha
Rat	-	-	19q11	Il27ra	interleukin 27 receptor subunit alpha

Previous and Unofficial Names

WSX-1 | cytokine receptor-like 1 | IL-27RA | TCCR | interleukin 27 receptor, alpha | interleukin 27 receptor

Database Links
Alphafold	Q6UWB1 (Hs), O70394 (Mm)
CATH/Gene3D	2.60.40.10
Ensembl Gene	ENSG00000104998 (Hs), ENSMUSG00000005465 (Mm), ENSRNOG00000005729 (Rn), ENSRNOG00000005747 (Rn)
Human Protein Atlas	ENSG00000104998 (Hs)
Pharos	Q6UWB1 (Hs)
UniProtKB	Q6UWB1 (Hs), O70394 (Mm)
Wikipedia	IL27RA (Hs)

Immunopharmacology Comments

This is the ligand binding subunit of the IL-27 receptor heterodimer, a complex with IL6ST (signal transducing subunit).

Immuno Process Associations

Immuno Process:  Chemotaxis & migration

Immuno Process:  Inflammation

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Physiological Consequences of Altering Gene Expression
MIce lacking Il27ra expression by their Treg cells develop more severe experimental autoimmune encephalomyelitis (EAE) than wild type mice, indicating that IL-27 is important for Treg function and control of autoimmunity. Species:  Mouse Tissue:  T regulatory cells. Technique:  References:  1