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interleukin 1 receptor associated kinase 2

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Target id: 2043

Nomenclature: interleukin 1 receptor associated kinase 2

Abbreviated Name: IRAK2

Family: Interleukin-1 receptor-associated kinase (IRAK) family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 625 3p25.3 IRAK2 interleukin 1 receptor associated kinase 2
Mouse - 622 6 52.82 cM Irak2 interleukin-1 receptor-associated kinase 2
Rat - 624 4q42 Irak2 interleukin-1 receptor-associated kinase 2
Previous and Unofficial Names Click here for help
interleukin-1 receptor-associated kinase 2
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  The ternary Death Domain complex of MyD88, IRAK4, and IRAK2
Resolution:  3.4Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number:
Immunopharmacology Comments
IRAK2 is one of the proximal mediators of IL-1 signalling via the IL-1 receptor, the other being IRAK1. It plays a part in IL-1-induced upregulation of the transcription factor NF-κB. IRAK2 interacts with TRAF6 and Myd88.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling


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1. Lin SC, Lo YC, Wu H. (2010) Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature, 465 (7300): 885-90. [PMID:20485341]

How to cite this page

Interleukin-1 receptor-associated kinase (IRAK) family: interleukin 1 receptor associated kinase 2. Last modified on 17/10/2018. Accessed on 20/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,