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interleukin 1 receptor associated kinase 2

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Target id: 2043

Nomenclature: interleukin 1 receptor associated kinase 2

Abbreviated Name: IRAK2

Family: Interleukin-1 receptor-associated kinase (IRAK) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 625 3p25.3 IRAK2 interleukin 1 receptor associated kinase 2
Mouse - 622 6 52.82 cM Irak2 interleukin-1 receptor-associated kinase 2
Rat - 624 4q42 Irak2 interleukin-1 receptor-associated kinase 2
Previous and Unofficial Names Click here for help
interleukin-1 receptor-associated kinase 2
Database Links Click here for help
Alphafold O43187 (Hs), Q8CFA1 (Mm), Q4QQS0 (Rn)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL4105759 (Hs)
Ensembl Gene ENSG00000134070 (Hs), ENSMUSG00000060477 (Mm), ENSRNOG00000021817 (Rn)
Entrez Gene 3656 (Hs), 108960 (Mm), 362418 (Rn)
Human Protein Atlas ENSG00000134070 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:3656 (Hs), mmu:108960 (Mm), rno:362418 (Rn)
OMIM 603304 (Hs)
Pharos O43187 (Hs)
RefSeq Nucleotide NM_001570 (Hs), NM_172161 (Mm), NM_001025422 (Rn)
RefSeq Protein NP_001561 (Hs), NP_751893 (Mm), NP_001020593 (Rn)
UniProtKB O43187 (Hs), Q8CFA1 (Mm), Q4QQS0 (Rn)
Wikipedia IRAK2 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  The ternary Death Domain complex of MyD88, IRAK4, and IRAK2
PDB Id:  3MOP
Resolution:  3.4Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
Immunopharmacology Comments
IRAK2 is one of the proximal mediators of IL-1 signalling via the IL-1 receptor, the other being IRAK1. It plays a part in IL-1-induced upregulation of the transcription factor NF-κB. IRAK2 interacts with TRAF6 and Myd88.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0006954 inflammatory response TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0001959 regulation of cytokine-mediated signaling pathway IMP
GO:0019221 cytokine-mediated signaling pathway IBA
GO:0070498 interleukin-1-mediated signaling pathway IMP
GO:0070555 response to interleukin-1 IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS

References

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1. Lin SC, Lo YC, Wu H. (2010) Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature, 465 (7300): 885-90. [PMID:20485341]

How to cite this page

Interleukin-1 receptor-associated kinase (IRAK) family: interleukin 1 receptor associated kinase 2. Last modified on 17/10/2018. Accessed on 10/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2043.