Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	520	12p13.32	DYRK4	dual specificity tyrosine phosphorylation regulated kinase 4
Mouse	-	632	6 F3	Dyrk4	dual-specificity tyrosine phosphorylation regulated kinase 4
Rat	-	-	4 q42	Dyrk4	dual specificity tyrosine phosphorylation regulated kinase 4

Previous and Unofficial Names

RAD51 associated protein 1 | Rad51ap1 | dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Database Links
Alphafold	Q9NR20 (Hs), Q8BI55 (Mm)
BRENDA	2.7.12.1
ChEMBL Target	CHEMBL1075115 (Hs)
Ensembl Gene	ENSG00000010219 (Hs), ENSMUSG00000030345 (Mm), ENSRNOG00000053178 (Rn)
Entrez Gene	8798 (Hs), 101320 (Mm), 312721 (Rn)
Human Protein Atlas	ENSG00000010219 (Hs)
KEGG Enzyme	2.7.12.1
KEGG Gene	hsa:8798 (Hs), mmu:101320 (Mm), rno:312721 (Rn)
OMIM	609181 (Hs)
Pharos	Q9NR20 (Hs)
RefSeq Nucleotide	NM_003845 (Hs), NM_207210 (Mm)
RefSeq Protein	NP_003836 (Hs), NP_997093 (Mm)
UniProtKB	Q9NR20 (Hs), Q8BI55 (Mm)
Wikipedia	DYRK4 (Hs)

Enzyme Reaction
EC Number: 2.7.12.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference leucettine L41 Hs Inhibition 6.3 pIC50 2 ⤷ pIC50 6.3 (IC50 5.2x10-7 M) [2]

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/DYRK4
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM JNK inhibitor V Hs Inhibitor Inhibition 65.0 Syk inhibitor Hs Inhibitor Inhibition 73.7 PDGF receptor tyrosine kinase inhibitor III Hs Inhibitor Inhibition 79.8 p38 MAP kinase inhibitor Hs Inhibitor Inhibition 81.5 Cdc2-like kinase inhibitor Hs Inhibitor Inhibition 82.3 Tpl2 kinase inhibitor Hs Inhibitor Inhibition 84.4 Syk inhibitor III Hs Inhibitor Inhibition 84.9 D4476 Hs Inhibitor Inhibition 85.6 PDGF receptor tyrosine kinase inhibitor II Hs Inhibitor Inhibition 86.0 Cdk4 inhibitor Hs Inhibitor Inhibition 86.0
Displaying the top 10 most potent ligands  View all ligands in screen »