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Interleukin-1 receptor-like 1

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Target id: 1735

Nomenclature: Interleukin-1 receptor-like 1

Family: Immunoglobulin-like family of IL-1 receptors

Contents:

Quaternary Structure: Complexes
Interleukin-33 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 556 2q12.1 IL1RL1 interleukin 1 receptor like 1 4
Mouse 1 567 1 19.19 cM Il1rl1 interleukin 1 receptor-like 1
Rat 1 566 9q22 Il1rl1 interleukin 1 receptor-like 1
Previous and Unofficial Names Click here for help
DER4 | IL33R | ST2 | ST2L | FIT1 | Fos-responsive gene 1 | Ly84 | ST2V
Database Links Click here for help
Alphafold Q01638 (Hs), P14719 (Mm), Q62611 (Rn)
CATH/Gene3D 2.60.40.10, 3.40.50.10140
ChEMBL Target CHEMBL4804256 (Hs)
Ensembl Gene ENSG00000115602 (Hs), ENSMUSG00000026069 (Mm), ENSRNOG00000014835 (Rn)
Entrez Gene 9173 (Hs), 17082 (Mm), 25556 (Rn)
Human Protein Atlas ENSG00000115602 (Hs)
KEGG Gene hsa:9173 (Hs), mmu:17082 (Mm), rno:25556 (Rn)
OMIM 601203 (Hs)
Pharos Q01638 (Hs)
UniProtKB Q01638 (Hs), P14719 (Mm), Q62611 (Rn)
Wikipedia IL1RL1 (Hs)
Immunopharmacology Comments
IL1RL1 (ST2) is the ligand binding subunit of the functional receptor for IL-33. It is mainly expressed on mast cells, eosinophils and other immune cells [2]. The ST2/IL-33 axis is recognized as playing an important role in the development/exacerbation of IgE-dependent inflammation such as asthma and atopic dermatitis [1,3]. Blockade of ST2 (and/or IL-33; see our comment regarding investigational anti-IL-33 mAb AMG-282) represent potential novel mechanisms for pharmaceutical intervention to suppress allergy and mast cell-eosinophil interplay.
Cell Type Associations
Immuno Cell Type:  Mast cells
References:  2
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0002114 interleukin-33 receptor activity IBA
GO:0004896 cytokine receptor activity TAS
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GO:0004908 interleukin-1 receptor activity IEA
GO:0032689 negative regulation of type II interferon production IEA
GO:0032722 positive regulation of chemokine production IEA
GO:0032754 positive regulation of interleukin-5 production IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0043032 positive regulation of macrophage activation IEA
GO:0050729 positive regulation of inflammatory response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002826 negative regulation of T-helper 1 type immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002826 negative regulation of T-helper 1 type immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
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GO:0002826 negative regulation of T-helper 1 type immune response IEA
GO:0043032 positive regulation of macrophage activation IEA
GO:0050729 positive regulation of inflammatory response IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0032722 positive regulation of chemokine production IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0043032 positive regulation of macrophage activation IEA

References

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1. Bandara G, Beaven MA, Olivera A, Gilfillan AM, Metcalfe DD. (2015) Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33. Eur J Immunol, 45 (11): 3034-44. [PMID:26256265]

2. Gangwar RS, Landolina N, Arpinati L, Levi-Schaffer F. (2017) Mast cell and eosinophil surface receptors as targets for anti-allergic therapy. Pharmacol Ther, 170: 37-63. [PMID:27773785]

3. Hsu CL, Neilsen CV, Bryce PJ. (2010) IL-33 is produced by mast cells and regulates IgE-dependent inflammation. PLoS ONE, 5 (8): e11944. [PMID:20689814]

4. Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T. (1992) Nucleotide sequence of a complementary DNA for human ST2. Biochim Biophys Acta, 1171 (2): 215-8. [PMID:1482686]

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor-like 1. Last modified on 22/03/2017. Accessed on 10/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1735.