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Granulocyte colony-stimulating factor receptor

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Target id: 1719

Nomenclature: Granulocyte colony-stimulating factor receptor

Family: Prolactin receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 836 1p34.3 CSF3R colony stimulating factor 3 receptor
Mouse 1 837 4 59.77 cM Csf3r colony stimulating factor 3 receptor
Rat - - 5q36 Csf3r colony stimulating factor 3 receptor
Previous and Unofficial Names Click here for help
CD114 | granulocyte colony-stimulating factor receptor | GCSFR
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the human GCSF-receptor signaling complex
PDB Id:  2D9Q
Resolution:  2.8Å
Species:  Human
References:  4
Natural/Endogenous Ligands Click here for help
G-CSF {Sp: Human}

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Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
G-CSF {Sp: Human} Peptide Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
pegfilgrastim Peptide Approved drug Primary target of this compound Hs Agonist - -
Agonist Comments
The granulocyte colony-stimulating factor receptor (CSF3R) is the primary target for the approved drugs filgrastim and pegfilgrastim.
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
anumigilimab Peptide Monkey Binding 9.3 pKd 3
pKd 9.3 (Kd 4.9x10-10 M) [3]
Description: Binding of immobilised antibody to cynomolgus monkey CSF3R
anumigilimab Peptide Primary target of this compound Hs Binding 8.9 pKd 3
pKd 8.9 (Kd 1.4x10-9 M) [3]
Description: Binding of immobilised antibody to hCSF3R
Immunopharmacology Comments
This nuclear receptor mediates the effects of the cytokine, colony stimulating factor 3 (CSF3). CSF3 regulates the production, differentiation, and function of granulocytes.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Atypical chronic myeloid leukemia
Orphanet: ORPHA98824
References:  2
Disease:  Chronic neutrophilic leukemia
Orphanet: ORPHA86829
References:  1-2
Disease:  Neutrophilia, hereditary
OMIM: 162830
Orphanet: ORPHA279943
Disease:  Severe congenital neutropenia
Description: Severe congenital neutropenia (SCN) is a heterogeneous disorder of hematopoiesis. The resulting subnormal neutrophil counts lead to early onset of severe bacterial infections. SCN can be caused by mutations in several genes including ELANE, GFI1, HAX1, G6PC3, VPS45, WASP and CSF3R. SCN1 is the commonest subtype and is caused by autosomal dominant inheritance of a defective ELANE gene.
Synonyms: Kostmann syndrome
OMIM: 202700, 617014, 610738, 613107, 612541, 615285, 300299, 616022


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1. Lasho TL, Mims A, Elliott MA, Finke C, Pardanani A, Tefferi A. (2014) Chronic neutrophilic leukemia with concurrent CSF3R and SETBP1 mutations: single colony clonality studies, in vitro sensitivity to JAK inhibitors and lack of treatment response to ruxolitinib. Leukemia, 28 (6): 1363-5. [PMID:24445868]

2. Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE et al.. (2013) Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med, 368 (19): 1781-90. [PMID:23656643]

3. Nash AD, Andrews AE, Baca M, Edwarda KM, Hardt MP, Panousis C, Dunlop FM. (2012) Antibodies against g-csfr and uses thereof. Patent number: WO2012171057A1. Assignee: Csl Limited. Priority date: 13/06/2011. Publication date: 20/12/2012.

4. Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R. (2006) Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. Proc Natl Acad Sci USA, 103 (9): 3135-40. [PMID:16492764]

How to cite this page

Prolactin receptor family: Granulocyte colony-stimulating factor receptor. Last modified on 19/10/2021. Accessed on 23/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,