ADAM8

Target id: 1656

Nomenclature: ADAM8

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	824	10q26.3	ADAM8	ADAM metallopeptidase domain 8
Mouse	1	826	7 F4	Adam8	a disintegrin and metallopeptidase domain 8
Rat	-	-	1q41	Adam8	ADAM metallopeptidase domain 8

Previous and Unofficial Names
Cell surface antigen MS2 \| a disintegrin and metalloproteinase domain 8 \| ADAM metallopeptidase domain 8 \| CD156a

Database Links
Specialist databases
MEROPS	M12.208 (Hs)
Other databases
Alphafold	P78325 (Hs), Q05910 (Mm)
BRENDA	3.4.24.-
CATH/Gene3D	3.40.390.10, 4.10.70.10
ChEMBL Target	CHEMBL5665 (Hs)
Ensembl Gene	ENSG00000151651 (Hs), ENSMUSG00000025473 (Mm), ENSRNOG00000017897 (Rn)
Entrez Gene	101 (Hs), 11501 (Mm), 499285 (Rn)
Human Protein Atlas	ENSG00000151651 (Hs)
KEGG Enzyme	3.4.24.-
KEGG Gene	hsa:101 (Hs), mmu:11501 (Mm), rno:499285 (Rn)
OMIM	602267 (Hs)
Pharos	P78325 (Hs)
RefSeq Nucleotide	NM_001109 (Hs), NM_001164490 (Hs), NM_001164489 (Hs), NM_007403 (Mm)
RefSeq Protein	NP_001157962 (Hs), NP_001157961 (Hs), NP_001100 (Hs), NP_031429 (Mm)
UniProtKB	P78325 (Hs), Q05910 (Mm)
Wikipedia	ADAM8 (Hs)

Enzyme Reaction

EC Number: 3.4.24.-

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Inhibitors

Key to terms and symbols

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Ligand											Sp.	Action	Value	Parameter	Reference
INCB3619											Hs	Inhibition	6.0	pIC₅₀	1
⤷	pIC₅₀ 6.0 (IC₅₀ 1x10^-6 M) [1]

Immunopharmacology Comments
ADAM8 is reported to drive acute allergen-induced airway inflammation in a mouse model, and effect negated by ADAM8-deficiency (antibody-induced or gene knockout) [3]. The potential roles of ADAM8 in inflammation regulation and in experimental asthma are reviewed in [4] and [2] respectively.

Immunopharmacology Comments

ADAM8 is reported to drive acute allergen-induced airway inflammation in a mouse model, and effect negated by ADAM8-deficiency (antibody-induced or gene knockout) [3]. The potential roles of ADAM8 in inflammation regulation and in experimental asthma are reviewed in [4] and [2] respectively.

Immuno Process Associations

Immuno Process:

Inflammation

Immuno Process:

T cell (activation)

Immuno Process:

Immune regulation

Immuno Process:

Immune system development

Immuno Process:

Cytokine production & signalling

Immuno Process:

Chemotaxis & migration

Immuno Process:

Cellular signalling

References

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1. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem, 16 (19): 8781-94. [PMID:18790648]

2. Matsuno O, Miyazaki E, Nureki S, Ueno T, Kumamoto T, Higuchi Y. (2006) Role of ADAM8 in experimental asthma. Immunol Lett, 102 (1): 67-73. [PMID:16154205]

3. Paulissen G, Rocks N, Guéders MM, Bedoret D, Crahay C, Quesada-Calvo F, Hacha J, Bekaert S, Desmet C, Foidart JM et al.. (2011) ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation. Eur J Immunol, 41 (2): 380-91. [PMID:21268008]

4. Zarbock A, Rossaint J. (2011) Regulating inflammation: ADAM8--a new player in the game. Eur J Immunol, 41 (12): 3419-22. [PMID:22125009]