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N-Acylphosphatidylethanolamine-phospholipase D

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Target id: 1398

Nomenclature: N-Acylphosphatidylethanolamine-phospholipase D

Abbreviated Name: NAPE-PLD

Family: N-Acylethanolamine turnover

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 393 7q22.1 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D
Mouse - 396 5 A3 Napepld N-acyl phosphatidylethanolamine phospholipase D
Rat - 396 4q11 Napepld N-acyl phosphatidylethanolamine phospholipase D
Previous and Unofficial Names Click here for help
FMP30 | chromosome 7 open reading frame 18, N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Database Links Click here for help
Alphafold Q6IQ20 (Hs), Q8BH82 (Mm), Q769K2 (Rn)
BRENDA 3.1.4.54
CATH/Gene3D 3.60.15.10
ChEMBL Target CHEMBL4630839 (Hs), CHEMBL2163172 (Mm)
Ensembl Gene ENSG00000161048 (Hs), ENSMUSG00000044968 (Mm), ENSRNOG00000011363 (Rn)
Entrez Gene 222236 (Hs), 242864 (Mm), 296757 (Rn)
Human Protein Atlas ENSG00000161048 (Hs)
KEGG Enzyme 3.1.4.54
KEGG Gene hsa:222236 (Hs), mmu:242864 (Mm), rno:296757 (Rn)
OMIM 612334 (Hs)
Pharos Q6IQ20 (Hs)
UniProtKB Q6IQ20 (Hs), Q8BH82 (Mm), Q769K2 (Rn)
Wikipedia NAPEPLD (Hs)
Enzyme Reaction Click here for help
EC Number: 3.1.4.54

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
LEI-401 Small molecule or natural product Hs Inhibition 7.6 pKi 3
⤷ pKi 7.6 (Ki 2.7x10-8 M) [3]
Description: hNAPE-PLD in vitro activity assay.
hexachlorophene Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibition 5.0 pIC50 1
⤷ pIC50 5.0 (IC50 9.8x10-6 M) [1]
bithionol Small molecule or natural product Ligand has a PDB structure Hs Inhibition 5.0 pIC50 1
⤷ pIC50 5.0 (IC50 1.07x10-5 M) [1]
ARN19874 Small molecule or natural product Hs Inhibition 4.5 pIC50 2
⤷ pIC50 4.5 (IC50 3.37x10-5 M) [2]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation

References

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1. Aggarwal G, Zarrow JE, Mashhadi Z, Flynn CR, Vinson P, Weaver CD, Davies SS. (2020) Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D. J Biol Chem, 295 (21): 7289-7300. [PMID:32284327]

2. Castellani B, Diamanti E, Pizzirani D, Tardia P, Maccesi M, Realini N, Magotti P, Garau G, Bakkum T, Rivara S et al.. (2017) Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD). Chem Commun (Camb.), 53 (95): 12814-12817. [PMID:29143042]

3. Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga ZV, Paloczi J et al.. (2020) Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat Chem Biol, 16 (6): 667-675. [PMID:32393901]

Contributors

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