Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	829	15q25.3	PDE8A	phosphodiesterase 8A
Mouse	-	823	7 D3	Pde8a	phosphodiesterase 8A
Rat	-	-		Pde8a	phosphodiesterase 8A

Previous and Unofficial Names

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Database Links
Alphafold	O60658 (Hs), O88502 (Mm)
BRENDA	3.1.4.17
CATH/Gene3D	1.10.1300.10
ChEMBL Target	CHEMBL4640 (Hs)
DrugBank Target	O60658 (Hs)
Ensembl Gene	ENSG00000073417 (Hs), ENSMUSG00000025584 (Mm), ENSRNOG00000019005 (Rn)
Entrez Gene	5151 (Hs), 18584 (Mm), 308776 (Rn)
Human Protein Atlas	ENSG00000073417 (Hs)
KEGG Enzyme	3.1.4.17
KEGG Gene	hsa:5151 (Hs), mmu:18584 (Mm), rno:308776 (Rn)
OMIM	602972 (Hs)
Pharos	O60658 (Hs)
UniProtKB	O60658 (Hs), O88502 (Mm)
Wikipedia	PDE8A (Hs)

Enzyme Reaction
EC Number: 3.1.4.17

Rank order of affinity (Human)

cyclic AMP >> cyclic GMP  [2]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference PF-04957325 Hs Inhibition 7.4 pIC50 3 ⤷ pIC50 7.4 (IC50 4.3x10-8 M) [3] dipyridamole Hs Inhibition 5.1 pIC50 2 ⤷ pIC50 5.1 (IC50 7.94x10-6 M) [2]

Immunopharmacology Comments

The PDE8A-Raf-1 kinase signaling complex has been shown to regulate CD4+ T cell motility, and PDE8A represents a novel target for control of T cell-mediated inflammation [1].