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phosphodiesterase 8A

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Target id: 1307

Nomenclature: phosphodiesterase 8A

Abbreviated Name: PDE8A

Family: Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 829 15q25.3 PDE8A phosphodiesterase 8A
Mouse - 823 7 D3 Pde8a phosphodiesterase 8A
Rat - - Pde8a phosphodiesterase 8A
Previous and Unofficial Names Click here for help
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction Click here for help
EC Number:
Rank order of affinity (Human)
cyclic AMP >> cyclic GMP  [2]

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PF-04957325 Small molecule or natural product Primary target of this compound Immunopharmacology Ligand Hs Inhibition 7.4 pIC50 3
pIC50 7.4 (IC50 4.3x10-8 M) [3]
dipyridamole Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.1 pIC50 2
pIC50 5.1 (IC50 7.94x10-6 M) [2]
Immunopharmacology Comments
The PDE8A-Raf-1 kinase signaling complex has been shown to regulate CD4+ T cell motility, and PDE8A represents a novel target for control of T cell-mediated inflammation [1].


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1. Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S. (2017) PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cell Signal, 40: 62-72. [PMID:28851628]

2. Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB. (1998) Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Biochem Biophys Res Commun, 246 (3): 570-7. [PMID:9618252]

3. Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. (2014) Advances in targeting cyclic nucleotide phosphodiesterases. Nat Rev Drug Discov, 13 (4): 290-314. [PMID:24687066]


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