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Malonyl-CoA decarboxylase

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Target id: 1275

Nomenclature: Malonyl-CoA decarboxylase

Abbreviated Name: MLYCD

Family: Decarboxylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 493 16q23.3 MLYCD malonyl-CoA decarboxylase
Mouse - 492 8 E1 Mlycd malonyl-CoA decarboxylase
Rat - 492 19q12 Mlycd malonyl-CoA decarboxylase
Previous and Unofficial Names Click here for help
MCD | malonyl-CoA decarboxylase, mitochondrial
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 10h [PMID: 20832306] Small molecule or natural product Hs Inhibition 9.3 pIC50 1
pIC50 9.3 (IC50 5x10-10 M) [1]


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1. Tang H, Yan Y, Feng Z, de Jesus RK, Yang L, Levorse DA, Owens KA, Akiyama TE, Bergeron R, Castriota GA et al.. (2010) Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett, 20 (20): 6088-92. [PMID:20832306]

How to cite this page

Decarboxylases: Malonyl-CoA decarboxylase. Last modified on 10/07/2018. Accessed on 13/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,