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Target id: 1250
Nomenclature: Inducible NOS
Abbreviated Name: iNOS
Family: Nitric oxide synthases
Annotation status:
Awaiting annotation/under development. Please contact us if you can help with annotation.
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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | - | NOS2 | nitric oxide synthase 2 | ||
Mouse | - | - | Nos2 | nitric oxide synthase 2, inducible | ||
Rat | - | - | Nos2 | nitric oxide synthase 2 |
Database Links ![]() |
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BRENDA | 1.14.13.39 |
CATH/Gene3D | 3.40.50.360 |
ChEMBL Target | CHEMBL4481 (Hs), CHEMBL3464 (Mm), CHEMBL3051 (Rn) |
DrugBank Target | P35228 (Hs) |
Ensembl Gene | ENSG00000007171 (Hs), ENSMUSG00000020826 (Mm), ENSRNOG00000011023 (Rn) |
Entrez Gene | 4843 (Hs), 18126 (Mm), 24599 (Rn) |
Human Protein Atlas | ENSG00000007171 (Hs) |
KEGG Enzyme | 1.14.13.39 |
KEGG Gene | hsa:4843 (Hs), mmu:18126 (Mm), rno:24599 (Rn) |
OMIM | 163730 (Hs) |
UniProtKB | P35228 (Hs), P29477 (Mm), Q06518 (Rn) |
Wikipedia | NOS2 (Hs) |
Enzyme Reaction ![]() |
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Products ![]() |
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Cofactors ![]() |
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Endogenous Substrate (Human) |
L-arginine |
Download all structure-activity data for this target as a CSV file
Inhibitors | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
The role of iNOS in immuno-oncology is reviewed in [1]. |
Immuno Process Associations | |||||||||
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1. Adams JL, Smothers J, Srinivasan R, Hoos A. (2015) Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov, 14 (9): 603-22. [PMID:26228631]
2. Collins JL, Shearer BG, Oplinger JA, Lee S, Garvey EP, Salter M, Duffy C, Burnette TC, Furfine ES. (1998) N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J. Med. Chem., 41 (15): 2858-71. [PMID:9667974]
3. Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P et al.. (2004) 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J. Med. Chem., 47 (12): 3320-3. [PMID:15163211]