Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	-		NOS2	nitric oxide synthase 2
Mouse	-	-		Nos2	nitric oxide synthase 2, inducible
Rat	-	-		Nos2	nitric oxide synthase 2

Previous and Unofficial Names

NOS2A | HEP-NOS | nitric oxide synthase 2A (inducible, hepatocytes) | Nitric oxide synthase 2 inducible | Nitric oxide synthase 2 inducible macrophage | inducible NO synthase | Nitric oxide synthase 2 / NOSII | inducible macrophage NOS | nitric oxide synthase 2

Database Links
BRENDA	1.14.13.39
CATH/Gene3D	3.40.50.360
ChEMBL Target	CHEMBL4481 (Hs), CHEMBL3464 (Mm), CHEMBL3051 (Rn)
DrugBank Target	P35228 (Hs)
Ensembl Gene	ENSG00000007171 (Hs), ENSMUSG00000020826 (Mm), ENSRNOG00000011023 (Rn)
Entrez Gene	4843 (Hs), 18126 (Mm), 24599 (Rn)
Human Protein Atlas	ENSG00000007171 (Hs)
KEGG Enzyme	1.14.13.39
KEGG Gene	hsa:4843 (Hs), mmu:18126 (Mm), rno:24599 (Rn)
OMIM	163730 (Hs)
UniProtKB	P35228 (Hs), P29477 (Mm), Q06518 (Rn)
Wikipedia	NOS2 (Hs)

Enzyme Reaction
EC Number: 1.14.13.39

Products
Product Species Reference NO Human L-citrulline Human

Cofactors
Cofactor Species Comments Reference Zn2+ Human NADPH Human heme Human flavin adenine dinucleotide Human flavin mononucleotide Human BH4 Human oxygen Human

Endogenous Substrate (Human)

L-arginine

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference L-NNA Hs Inhibition 6.2 pKi 2 ⤷ pKi 6.2 (Ki 6.7x10-7 M) [2] GW274150 Hs Inhibition 7.2 pIC50 3 ⤷ pIC50 7.2 (IC50 7x10-8 M) [3]

Immunopharmacology Comments

The role of iNOS in immuno-oncology is reviewed in [1].

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 4 GO processes GO:0002227 innate immune response in mucosa NAS GO:0006954 inflammatory response TAS GO:1900015 regulation of cytokine production involved in inflammatory response IDA click arrow to show/hide IEA associations GO:0071346 cellular response to interferon-gamma IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes GO:1900015 regulation of cytokine production involved in inflammatory response IDA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 9 GO processes GO:0019221 cytokine-mediated signaling pathway TAS GO:0034612 response to tumor necrosis factor IMP GO:0071345 cellular response to cytokine stimulus ISO GO:0071347 cellular response to interleukin-1 IEP GO:0071356 cellular response to tumor necrosis factor IEP GO:0072604 interleukin-6 secretion IDA GO:0072606 interleukin-8 secretion IDA GO:1900015 regulation of cytokine production involved in inflammatory response IDA click arrow to show/hide IEA associations GO:0071346 cellular response to interferon-gamma IEA