- Guide to PHARMACOLOGY
Synonyms: compound 2 [PMID: 9667974] | nitroarginine
Compound class: Synthetic organic
Comment: L-NNA is an arginine analogue used as a biochemical tool in the study of nitric oxide and its biological effects. L-NNA inhibits the endothelial and neuronal isoforms of nitric oxide synthase (NOS), eNOS and nNOS respectively more potently than the inducible iNOS .
Selective nNOS inhibitors are being pursued for their potential to treat neurological disorders caused by excessive production of nitric oxide.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: l-nna
|Compound class||Synthetic organic|
|compound 2 [PMID: 9667974] | nitroarginine|
|CAS Registry No.||2149-70-4|
|GtoPdb PubChem SID||252827417|
|RCSB PDB Ligand||NRG|
|Search Google for chemical match using the InChIKey||MRAUNPAHJZDYCK-BYPYZUCNSA-N|
|Search Google for chemicals with the same backbone||MRAUNPAHJZDYCK|
|Search UniChem for chemical match using the InChIKey||MRAUNPAHJZDYCK-BYPYZUCNSA-N|
|Search UniChem for chemicals with the same backbone||MRAUNPAHJZDYCK|
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Cat. No. 0664