Endothelial NOS | Nitric oxide synthases | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Endothelial NOS

Target id: 1249

Nomenclature: Endothelial NOS

Abbreviated Name: eNOS

Family: Nitric oxide synthases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - NOS3 nitric oxide synthase 3
Mouse - - Nos3 nitric oxide synthase 3, endothelial cell
Rat - - Nos3 nitric oxide synthase 3
Previous and Unofficial Names
endothelial nitric oxide synthase | EC-NOS | endothelial NOS | constitutive NOS | cNOS | Nitric oxide synthase 3 / NOSIII | nitric oxide synthase 3 (endothelial cell) | nitric oxide synthase 3
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.13.39
Products
Product Species Reference
NO Human
L-citrulline Human
Cofactors
Cofactor Species Comments Reference
Zn2+ Human
NADPH Human
heme Human
flavin adenine dinucleotide Human
flavin mononucleotide Human
BH4 Human
oxygen Human
Endogenous Substrate (Human)
L-arginine

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
L-NNA Hs Inhibition 7.5 pKi 1
pKi 7.5 (Ki 3x10-8 M) [1]
GW274150 Hs Inhibition 4.5 pIC50 2
pIC50 4.5 (IC50 3.4x10-5 M) [2]

References

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1. Collins JL, Shearer BG, Oplinger JA, Lee S, Garvey EP, Salter M, Duffy C, Burnette TC, Furfine ES. (1998) N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J. Med. Chem., 41 (15): 2858-71. [PMID:9667974]

2. Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P et al.. (2004) 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J. Med. Chem., 47 (12): 3320-3. [PMID:15163211]

Contributors

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