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Organic cation transporter 2

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Target id: 1020

Nomenclature: Organic cation transporter 2

Abbreviated Name: OCT2

Systematic Nomenclature: SLC22A2

Family: Organic cation transporters (OCT)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 555 6q25.3 SLC22A2 solute carrier family 22 member 2
Mouse 12 553 17 8.61 cM Slc22a2 solute carrier family 22 (organic cation transporter), member 2
Rat 12 555 1q11 Slc22a2 solute carrier family 22 member 2
Previous and Unofficial Names Click here for help
OCT2r | organic cation transporter 2 | solute carrier family 22 (organic cation transporter), member 2 | Orct2 | solute carrier family 22 (organic cation transporter)
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC22A2 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
metformin Hs - - 2
cisplatin Hs - - 2
Stoichiometry Click here for help

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
decynium 22 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pKi 1
pKi 7.0 (Ki 1x10-7 M) [1]
Description: Measuring inhibition of tetraethylammonium (TEA) uptake via OCT2 expressed in Xenopus oocytes.


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1. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H. (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol, 16 (7): 871-81. [PMID:9260930]

2. Koepsell H. (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med, 34 (2-3): 413-35. [PMID:23506881]


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