Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	372	2q12.1	GPR45	G protein-coupled receptor 45	2
Mouse	7	373	1 B	Gpr45	G protein-coupled receptor 45
Rat	7	373	9q22	Gpr45	G protein-coupled receptor 45

Previous and Unofficial Names

PSP24 | high-affinity lysophosphatidic acid receptor | PSP24alpha | PSP24A

Database Links
Specialist databases
GPCRdb	gpr45_human (Hs), gpr45_mouse (Mm)
Other databases
Alphafold	Q9Y5Y3 (Hs), Q9EQQ4 (Mm)
ChEMBL Target	CHEMBL4523928 (Hs)
Ensembl Gene	ENSG00000135973 (Hs), ENSMUSG00000041907 (Mm), ENSRNOG00000016446 (Rn)
Entrez Gene	11250 (Hs), 93690 (Mm), 301372 (Rn)
Human Protein Atlas	ENSG00000135973 (Hs)
KEGG Gene	hsa:11250 (Hs), mmu:93690 (Mm), rno:301372 (Rn)
OMIM	604838 (Hs)
Pharos	Q9Y5Y3 (Hs)
RefSeq Nucleotide	NM_007227 (Hs), NM_053107 (Mm), NM_001106906 (Rn)
RefSeq Protein	NP_009158 (Hs), NP_444337 (Mm), NP_001100376 (Rn)
UniProtKB	Q9Y5Y3 (Hs), Q9EQQ4 (Mm)
Wikipedia	GPR45 (Hs)

Tissue Distribution
Basal forebrain, frontal cortex, caudate, liver Species:  Human Technique:  Northern blot References:  2
Neuronal cells, such as olfactory mitral cells, cortical neurons, hippocampal pyramidal cells, purkinje cells in the cerebellum Species:  Mouse Technique:  in situ hybridisation References:  1
Brain Species:  Mouse Technique:  Northern blot References:  1
Tissue Distribution Comments
No transcripts of GPR45 were detected in thalamus, hippocampus or putamen [2]. The expression of GPR45 in mouse brain starts from E13 and remains constant throughout adulthood [1].

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  L312F Global MAF (%):  10 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|12|2|16 Minor allele count:  T=0.096/209 SNP accession:  VAR_049394, rs35946826 Validation:  1000 Genomes, HapMap