Gene and Protein Information
class A G protein-coupled receptor: thought to be a pseudogene in man though functional in rodents
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	343	6q23.2	TAAR3P	trace amine associated receptor 3, pseudogene	1
Mouse	7	343	10 A4	Taar3	trace amine-associated receptor 3
Rat	7	342	1p12	Taar3	trace amine-associated receptor 3

Previous and Unofficial Names

GPR57 | G protein-coupled receptor 57 | trace amine receptor 3 | TAAR3 | trace amine associated receptor 3 (gene/pseudogene)

Database Links
Specialist databases
GPCRdb	taar3_human (Hs), taar3_mouse (Mm), taar3_rat (Rn)
Other databases
Alphafold	Q9P1P4 (Hs), Q5QD16 (Mm), Q5QD24 (Rn)
Ensembl Gene	ENSG00000179073 (Hs), ENSMUSG00000069708 (Mm), ENSRNOG00000025982 (Rn)
Entrez Gene	9288 (Hs), 493809 (Mm), 494319 (Rn)
Human Protein Atlas	ENSG00000179073 (Hs)
KEGG Gene	hsa:9288 (Hs), mmu:493809 (Mm), rno:494319 (Rn)
Pharos	Q9P1P4 (Hs)
RefSeq Nucleotide	NM_003967 (Hs), NM_001008429 (Mm), NM_001009532 (Rn)
RefSeq Protein	NP_001008429 (Mm), NP_001009532 (Rn)
UniProtKB	Q9P1P4 (Hs), Q5QD16 (Mm), Q5QD24 (Rn)
Wikipedia	TAAR3P (Hs)

Natural/Endogenous Ligands
isoamylamine
Comments: probable pseudogene.

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference isoamylamine Mm Full agonist 5.0 pEC50 2 ⤷ pEC50 5.0 (EC50 1x10-5 M) [2]
Agonist Comments
Cyclohexylamine has been shown to be an agonist at this receptor in mice [2]. It has been shown that the agonists of murine TAAR3 do not activate intact primate and mammalian orthologs [3].

Tissue Distribution
Olfactory epithelium Species:  Mouse Technique:  In situ hybridisation and RT-PCR. References:  2

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!