Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	333	Xq21.1	GPR174	G protein-coupled receptor 174
Mouse	7	335	X D	Gpr174	G protein-coupled receptor 174
Rat	7	335	Xq31	Gpr174	G protein-coupled receptor 174

Previous and Unofficial Names

FKSG79

Database Links
Specialist databases
GPCRdb	gp174_human (Hs), gp174_mouse (Mm)
Other databases
Alphafold	Q9BXC1 (Hs), Q3U507 (Mm)
ChEMBL Target	CHEMBL3562167 (Hs), CHEMBL3813587 (Mm)
Ensembl Gene	ENSG00000147138 (Hs), ENSMUSG00000073008 (Mm), ENSRNOG00000032970 (Rn)
Entrez Gene	84636 (Hs), 213439 (Mm), 302373 (Rn)
Human Protein Atlas	ENSG00000147138 (Hs)
KEGG Gene	hsa:84636 (Hs), mmu:213439 (Mm), rno:302373 (Rn)
OMIM	300903 (Hs)
Pharos	Q9BXC1 (Hs)
RefSeq Nucleotide	NM_032553 (Hs), NM_001033251 (Mm), NM_001106938 (Rn)
RefSeq Protein	NP_115942 (Hs), NP_001028423 (Mm), NP_001100408 (Rn)
UniProtKB	Q9BXC1 (Hs), Q3U507 (Mm)
Wikipedia	GPR174 (Hs)

Natural/Endogenous Ligands
lysophosphatidylserine
Comments: Proposed ligand, two publications

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference lysophosphatidylserine Hs Full agonist 7.1 pEC50 2 ⤷ pEC50 7.1 (EC50 8.1x10-8 M) [2]
Agonist Comments
GPR174 has been shown to be activated by lysophosphatidylserine, with coupling to cAMP and ERK [2,4].

Immuno Process Associations

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 1 GO processes GO:0032703 negative regulation of interleukin-2 production IDA

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0043029 T cell homeostasis IEA

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Clinically-Relevant Mutations and Pathophysiology
Disease:  Graves' disease Disease Ontology: DOID:12361 References:  1,5

Gene Expression and Pathophysiology Comments

GPR174 was found to be overexpressed in subcutaneous melanomametastases [3].

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Description:  Amino acid change associated with risk for Graves' disease Amino acid change:  S162P Nucleotide change:  519C>T Global MAF (%):  49 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 37|41|46|62 Minor allele count:  C=0.489/811 SNP accession:  rs3827440 Validation:  1000 Genomes, HapMap, Frequency References:  1
Type:  Single nucleotide polymorphism Species:  Human Description:  Nucleotide transition A>C at location X:78497118 associated with risk for Graves' disease. No amino acid change reported. Global MAF (%):  0.49 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 40|41|43|62 Minor allele count:  C=0.485/802 SNP accession:  rs5912838 Validation:  1000 Genomes, HapMap, Frequency References:  5
Biologically Significant Variant Comments
A number of rare single nucleotide polymorphisms are reported by Chu et al. in their genome-wide assocation study as being associated with Graves' disease. However, with the exception of rs3827440, none of these variants occured at a frequency of more than 5% in the population studied [1].